Integrative Biology Faculty

Yi Liu, Ph.D.
Program Chair
Liu Lab
Research Interests: Molecular mechanisms of circadian clocks 


Massimo Attanasio, M.D.
Assistant Professor
Research Interests:
Genetics of inherited kidney diseases, human genetics, molecular genetics, molecular biology


Ilya Bezprozvanny, Ph.D.
Professor
Bezprozvanny Lab
Research Interests: Neuronal calcium signaling and neurodegeneration; molecular mechanisms of Huntington's and Alzheimer's disease; calcium channels; synaptic transmission


Perry Bickel, M.D.
Associate Professor
Research Interests: Cellular lipid storage and utilization, specifically with respect to the function of perilipin family proteins


Rolf A. Brekken, Ph.D.
Associate Professor
Brekken Lab
Research Interests: Tumor-host interactions in pancreatic cancer as an avenue for the development of novel therapy; interplay between neoplastic genetic alterations, changes in the extracellular matrix, and angiogenesis in the development and progression of pancreatic cancer; gene therapy to restore SMAD4 expression in tumor cells; blocking VEGF-induced angiogenesis in tumors; function of the matricellular protein SPARC in tumor development


Michael S. Brown, M.D.
Professor
Brown/Goldstein Lab
Research Interests: Unraveling the mechanism by which the SREBP pathway regulates cholesterol metabolism at the molecular, cellular, and whole-body levels


Stephen C. Cannon, M.D., Ph.D.
Professor
Cannon Lab
Research Interests: Ion channel biophysics; neuromuscular disorders; mathematical modeling


Benjamin Chen, Ph.D.
Associate Professor
Chen Lab
Research Interests: DNA damage response; repair of DNA double-strand breaks


George N. DeMartino, Ph.D.
Professor
DeMartino Lab
Research Interests: Cell physiology; regulation of growth and atrophy; protein degradation; intracellular proteases; ubiquitin/proteasome pathway of protein degradation


Amelia J. Eisch, Ph.D.
Associate Professor
Eisch Lab
Research Interests: Adult mammalian neurogenesis and growth factors; cell-cycle analysis of adult neural stem cells in vivo; regulation of endogenous cell cycle proteins in psychiatric disorders such as addiction, depression, and Alzheimer’s disease; transgenic manipulation of adult mammalian neurogenesis


Joel K. Elmquist, D.V.M., Ph.D.
Professor
Elmquist Lab
Research Interests: Functional neuroanatomy of the mammalian hypothalamus


Andrew Feranchak, M.D.
Associate Professor
Feranchak Lab 
Research Interests: Hepatobiliary transport, mechanisms of bile formation, biophysical characterization of membrane ion channels, cell volume regulation, cholestatic liver disease


Christine Garcia, M.D., Ph.D.
Associate Professor
Garcia Lab
Research Interests: Genetic approaches to identifying primary determinants of lung disease


Joseph Garcia, M.D., D.Phil.
Associate Professor
Research Interests: Integrative biological studies of hypoxia-inducible transcription factors; identification of genetic factors controlling the cardiovascular-respiratory response to hypoxia


Laurent Gautron, Ph.D.
Assistant Professor
Gautron Lab


Dwight C. German, Ph.D.
Professor
German Lab
Research Interests: Mechanisms of neurodegeneration in neurological and psychiatric disorders, using human post-mortem tissue and animal models


Subroto Ghose, M.D., Ph.D.
Associate Professor
Ghose Lab
Research Interests: Neurobiology of schizophrenia using animal models, human post-mortem tissue, and human imaging approaches


Joseph L. Goldstein, M.D.
Professor
Brown/Goldstein Lab
Research Interests: Unraveling the mechanism by which the SREBP pathway regulates cholesterol metabolism at the molecular, cellular, and whole body levels


Frederick Grinnell, Ph.D.
Professor
Grinnell Lab
Research Interests: Cell signaling during wound repair; cell motility and contractility in wound contraction; MAP kinase and other signaling pathways regulating cellular reorganization of collagen matrices stimulated by platelet-derived growth factor, lysophosphatidic acid, and transforming growth factor beta


Rana Gupta, Ph.D.
Assistant Professor
Gupta Lab

Research Interests: Transcriptional control of fat cell development and adipose tissue expansion in obesity; manipulating the adipose lineage as a therapeutic treatment for metabolic disease


Joachim J. A. Herz, M.D.
Professor
Herz Lab
Research Interests: Molecular genetics; genetic manipulation of neuronal apoE receptors in mice; mechanisms of brain development, neurogenesis, and Alzheimer’s disease


Joseph A. Hill, M.D., Ph.D.
Professor
Hill Lab
Research Interests: Molecular signaling processes in cardiac hypertrophy and failure; mechanisms of structural, functional, and electrophysiological remodeling, using genetic and surgical mice models


Sandra L. Hofmann, M.D., Ph.D.
Professor
Research Interests: Role of lipid-metabolizing enzymes in cell metabolism and signal transduction; covalent modification of proteins by the fatty acid palmitate; the study of enzymes that transfer the palmitate on and off modified proteins


William Holland, Ph.D.
Assistant Professor
Holland Lab
Research Interests:Our lab focuses on understanding the role of sphingolipids in metabolic disease.  Modulating the flux of these lipids can have profound influences on glucose homeostasis, energy homeostasis, cell survival, and cancer biology.


Jay Horton, M.D.
Professor
Horton Lab
Research Interests: Hepatic steatosis; lipid metabolism


Ming-Chang Hu, M.D., Ph.D.
Assistant Professor
Research Interests: Abnormal mineral metabolism and dysregulation of Klotho/FGF23 axis related to acute kidney injury and chronic kidney disease, and to the complications in kidney diseases


Chou-Long Huang, M.D., Ph.D.
Professor
Huang Lab
Research Interests: Ion channels related to renal physiology and diseases, including renal potassium channel ROMK, epithelial calcium channel, and polycystic kidney disease protein related channels


Tae Hyun Hwang, Ph.D.
Assistant Professor
Hwang Lab
Research Interests: Bioinformatics, computational biology, network analysis, and next generation sequencing analysis


Peter Igarashi, M.D.
Professor
Igarashi Lab
Research Interests: Transcriptional control of tissue-specific gene expression and organogenesis; polycystic kidney disease


Kristine E. Kamm, Ph.D.
Professor
Kamm-Stull Lab
Research Interests: Muscle physiology; regulation of contractile and motile processes in smooth- and non-muscle cells  


W. Lee Kraus, Ph.D.
Professor
Kraus Lab
Research Interests: Cellular signaling, gene regulation, and epigenetic control in the chromatin environment of the nucleus. Biological systems include: reproduction, cancer, inflammation, adipogenesis, stem cells, differentiation.


Lu Q. Le, M.D., Ph.D.
Assistant Professor
Le Lab
Research Interests: Tumor cell of origin; roles of tumor microenvironment in cancer development; cellular and molecular mechanisms of neurofibromatosis; stem cell and cancer biology


Guosheng Liang, Ph.D.
Associate Professor
Liang Lab
Research Interests: Cholesterol homeostasis; metabolic diseases such as obesity and diabetes; transcriptional regulation


Mala Mahendroo, Ph.D.
Associate Professor
Mahendroo Lab
Research Interests: Parturition (the process of labor); cervical ripening; male and female reproductive biology


Pradeep Mammen, M.D.
Associate Professor
Research Interests: Internal Medicine; treatment and management of patients with heart failure and the molecular mechanisms underlying this clinical entity. Currently, I run a molecular cardiology laboratory focused on understanding how regulation of the metabolic and redox states of muscle progenitor cells and myocytes can be modulated to serve as potential therapeutic targets for various cardiac and skeletal myopathies. Ultimately, the ability to selectively regulate the metabolic and redox states within these cells may provide opportunities for the development of novel therapeutic approaches to the treatment of patients with various myopathies.


David J. Mangelsdorf, Ph.D.
Professor
Mangelsdorf/Kliewer Lab
Research Interests: Mechanism of action of nuclear hormone receptors; transcriptional regulation of lipid metabolism; role of retinoids and cancer


Steven McKnight, Ph.D.
Professor
McKnight Lab
Research Interests: Subset of transcription factors that are gene-specific; regulation of transcription-factor function at a biochemical level with keen attention to biological relevance


Carole R. Mendelson, Ph.D.
Professor
Mendelson Lab
Research Interests: Molecular mechanisms in tissue-specific, developmental, and hormonal regulation of eukaryotic gene expression


Chieko Mineo, Ph.D.
Associate Professor
Shaul/Mineo Lab
Research Interests: Molecular basis of pathogenesis of antiphospholipid syndrome; role of Pentraxin C Reactive protein in metabolic syndrome; biology of lipoproteins and their receptors


Orson Moe, M.D.
Professor
Moe Lab
Research Interests: Regulation of mammalian water and electrolyte homeostasis, including sodium, calcium, and acid-base metabolism and epithelial transport


Nancy Monson, Ph.D.
Associate Professor
Monson Lab
Research Interests: Translational research; immune responses in autoimmune disease; the role of the immune system in neurological diseases of the brain


Lisa Monteggia, Ph.D.
Professor
Monteggia Lab
Research Interests: Development of animal models for psychiatric diseases; growth factors and depression; role of MeCP2 in mediating autistic-like behavior; transcriptional repression in neurons


Nikhil Munshi, M.D., Ph.D.
Assistant Professor
Munshi Lab
Research Interests: Cardiac development; transcriptional regulation; human genetics; arrhythmogenesis. The cardiac conduction system is an electrically coupled structure within the heart responsible for initiation and propagation of each heartbeat.  Our lab is interested in elucidating the transcriptional mechanisms that dictate formation of the cardiac conduction system and its impact on the establishment of normal and pathological cardiac rhythms


Eric N. Olson, Ph.D.
Professor
Olson Lab
Research Interests: Transcriptional control of cell differentiation; muscle development


Juan Pascual, M.D., Ph.D.
Associate Professor
Research Interests: Animal and cellular models of neurogenetic disorders; synaptic transmission in experimental epilepsies; disorders of brain energy metabolism; developmental neurobiology; genotype:phenotype correlations in novel childhood encephalopathies; clinical pediatric neurology


Vishal Patel, M.D.
Assistant Professor
Research Interests: Studying the roles of miRNAs in kidney development and kidney diseases


Joyce Repa, Ph.D.
Associate Professor
Research Interests: How nuclear receptors control the expression of ABC transport proteins and the consequences of this regulation on lipid balance with respect to atherosclerosis, diabetes, and brain physiology


Charles Rosenfeld, M.D.
Professor
Research Interests: Cardiovascular adaptation during development and pregnancy; maturation and ontogeny of visceral and vascular smooth-muscle protein expression and function; regulation and function of angiotensin II receptor subtypes during development and pregnancy; mechanisms related to estrogen-induced vasodilation and modulation of uteroplacental blood flow in pregnancy


Beverly A. Rothermel, Ph.D.
Associate Professor
Rothermel Lab
Research Interests: Internal Medicine; control of muscle remodeling during development and disease; circadian control of cardiac function and the role of RCAN1 (Down Syndrome Critical Region 1), a regulator of the calcium-dependent phosphatase calcineurin


Rashmin C. Savani, M.D.
Professor
Research Interests: Cell and mouse models to investigate the mechanisms of extracellular matrix regulation of lung development and injury, in particular, the interaction of hyaluronan (hyaluronic acid) with specific receptors to regulate cell migration in pulmonary vascular development, innate immunity, and inflammatory responses to injury


Philipp Scherer, Ph.D.
Professor
Scherer Lab
Research Interests: Identification and physiological characterization of novel secretory proteins that serve as potential links between the adipocyte and the processes of whole body energy homeostasis, inflammation, and cancer, thereby defining novel targets for pharmacological intervention and further defining the role of adipose tissue as an endocrine organ


Philip W. Shaul, M.D.
Professor
Shaul/Mineo/Umentani Lab
Research Interests: Endothelial cell biology, vascular development and disease; signaling molecules in endothelial cell caveolae/lipid rafts


Rhonda F. Souza, M.D.
Professor
Research Interests: Internal Medicine/VA Medical Center;  investigate the molecular mechanisms involved in the development and neoplastic progression of Barrett’s esophagus, focusing on the intracellular signaling mechanisms and biologic relevance of acid and/or bile acid exposure, the components of reflux, on Barrett’s esophagus using animal models, cell culture, and human biopsy tissues


James T. Stull, Ph.D.
Professor
Kamm-Stull Lab
Research Interests: Myosin phosphorylation in the actin cytoskeleton and cell motility; modulation by signal-transduction pathways involving Ca2 and small GTP-dependent proteins


Philip J. Thomas, Ph.D.
Professor
Thomas Lab
Research Interests: Function and structural development of ATP-dependent membrane proteins, including CFTR


Madhukar H. Trivedi, M.D.
Professor
Research Interests:  


Benjamin Tu, Ph.D.
Associate Professor
Tu Lab
Research Interests: Metabolic cycles; mechanisms by which fundamental processes (e.g., cell growth and division, transcription, mitochondria homeostasis) are coupled to cellular metabolic state; yeast


Roger H. Unger, M.D.
Professor
Unger Lab
Research Interests: Diabetes, obesity, lipotoxicity, internal medicine, islet physiology, and pathophysiology


Steven Vernino, M.D., Ph.D.
Professor
Vernino Lab
Research Interests: Animal models of autoimmune autonomic neuropathy, serologic evaluation of patients with dysautonomia, disorders of neuromuscular hyperexcitability, paraneoplastic neurological syndromes


Yihong Wan, Ph.D.
Assistant Professor
Wan Lab
Research Interests: Transcriptional regulation of development, metabolism and cancer by nuclear receptors using the skeleton and the mammary gland as model systems


Richard Wang, M.D., Ph.D.
Assistant Professor
Research Interests: Regulation of glucose uptake; autophagy and skin cancer


Kevin W. Williams, Ph.D.
Assistant Professor
Research Interests: Understanding the cellular mechanisms that contribute to the coordinated control of food intake, body weight, and glucose homeostasis


Guanghua (Andy) Xiao, Ph.D. 
Associate Professor
Xiao Lab
Research Interests: Statistical methods in biomedical research, bioinformatics and computer software development, computer algorithm and database


Hiromi Yanagisawa, M.D., Ph.D.
Associate Professor
H. Yanagisawa Lab
Research Interests: Molecular components of the vascular wall during development and disease


Masashi Yanagisawa, M.D., Ph.D.
Professor
M. Yanagisawa Lab
Research Interests: Identification and characterization of new signaling molecules that regulate vital functions such as sleep, appetite, and blood pressure


Jin Ye, Ph.D.
Associate Professor
Ye Lab
Research Interests: Host proteins required for hepatitis C virus replication; regulation of geranylgeranyl lipid homeostasis; regulated intramembrane proteolysis


Helen L. Yin, Ph.D.
Professor
Yin Lab
Research Interests: Actin cytoskeletons of nonmuscle cells, including reorganization in response to extracellular signals; structure/function relationships of the gelsolin family of actin regulatory proteins


Chengcheng (Alec) Zhang
Associate Professor 
Zhang Lab
Research Interests: Mechanisms by which the cell fates of adult stem cells are regulated, and the interaction of adult stem cells and their in vivo microenvironment; ex vivo expansion of HSCs for cell therapy and gene therapy; the interplay between stem cells and cancer


Jeffrey M. Zigman, M.D., Ph.D.
Associate Professor
Zigman Lab
Research Interests: Identification of CNS targets of ghrelin action, the study of ghrelin cell physiology, functional neuroanatomy of the mammalian hypothalamus


Andrew R. Zinn, M.D., Ph.D.
Professor
Zinn Lab
Research Interests: Human genetic diseases, infertility, obesity, sex chromosome abnormalities

Associate Members

These faculty members do not accept graduate students. They participate in teaching, co-mentoring, exam and dissertation committees, and all other program responsibilities.

Shin Yamazaki, Ph.D.
Associate Professor
Yamazaki Lab 
Research Interests: Circadian control of cell cycle