Integrative Biology Faculty

Yi Liu, Ph.D.

Yi Liu, Ph.D., Program Chair
Liu Lab
Research Interests: Molecular mechanisms of circadian clocks

 

Ilya Bezprozvanny, Ph.D., Professor
Bezprozvanny Lab
Research Interests: Neuronal calcium signaling and neurodegeneration; molecular mechanisms of Huntington's and Alzheimer's disease; calcium channels; synaptic transmission

 

Perry Bickel, M.D., Associate Professor
Research Interests: Cellular lipid storage and utilization, specifically with respect to the function of perilipin family proteins

 

Rolf A. Brekken, Ph.D., Professor
Brekken Lab
Research Interests: Tumor microenvironment, epithelial plasticity, immune therapy, angiogenesis, metastasis, ECM signaling, matricellular proteins 

 

Michael S. Brown, M.D., Professor
Brown/Goldstein Lab
Research Interests: Unraveling the mechanism by which the SREBP pathway regulates cholesterol metabolism at the molecular, cellular, and whole-body levels

 

Benjamin Chen, Ph.D., Associate Professor
Chen Lab
Research Interests: DNA damage response; repair of DNA double-strand breaks

 

George N. DeMartino, Ph.D., Professor
DeMartino Lab
Research Interests: Cell physiology; regulation of growth and atrophy; protein degradation; intracellular proteases; ubiquitin/proteasome pathway of protein degradation

 

Joel K. Elmquist, D.V.M., Ph.D., Professor
Elmquist Lab
Research Interests: Functional neuroanatomy of the mammalian hypothalamus

 

Andrew Feranchak, M.D., Associate Professor
Feranchak Lab 
Research Interests: Hepatobiliary transport, mechanisms of bile formation, biophysical characterization of membrane ion channels, cell volume regulation, cholestatic liver disease

 

Christine Garcia, M.D., Ph.D., Professor
Garcia Lab
Research Interests: Genetic approaches to identifying primary determinants of lung disease

 

Joseph Garcia, M.D., Ph.D., Associate Professor
Research Interests: Integrative biological studies of hypoxia-inducible transcription factors; identification of genetic factors controlling the cardiovascular-respiratory response to hypoxia

 

Laurent Gautron, Ph.D., Assistant Professor
Gautron Lab
Research Interests: Autonomic pathways involved in the pathophysiology of chronic metabolic disease in the mouse

 
Yi Liu, Ph.D.

Adi F. Gazdar, M.D., Professor
Gazdar Lab
Research Interests: Pathology, Lung Cancer, Molecular Biology, Cancer Pathogenesis

 

Dwight C. German, Ph.D., Professor
German Lab
Research Interests: Mechanisms of neurodegeneration in neurological and psychiatric disorders, using human post-mortem tissue and animal models

 

Subroto Ghose, M.D., Ph.D., Associate Professor
Ghose Lab
Research Interests: Neurobiology of schizophrenia using animal models, human post-mortem tissue, and human imaging approaches

 

Joseph L. Goldstein, M.D., Professor
Brown/Goldstein Lab
Research Interests: Unraveling the mechanism by which the SREBP pathway regulates cholesterol metabolism at the molecular, cellular, and whole-body levels

 

Frederick Grinnell, Ph.D., Professor
Grinnell Lab
Research Interests: Wound repair, cell mechanics, cell-matrix interactions, bioethics, science education, science policy

 

Rana Gupta, Ph.D., Assistant Professor
Gupta Lab
Research Interests: Transcriptional control of fat cell development and adipose tissue expansion in obesity; manipulating the adipose lineage as a therapeutic treatment for metabolic disease

 

Joachim J.A. Herz, M.D., Professor
Herz Lab
Research Interests: Molecular genetics; genetic manipulation of neuronal apoE receptors in mice; mechanisms of brain development, neurogenesis, and Alzheimer’s disease

 

Joseph A. Hill, M.D., Ph.D., Professor
Hill Lab
Research Interests: Molecular signaling processes in cardiac hypertrophy and failure; mechanisms of structural, functional, and electrophysiological remodeling, using genetic and surgical mice models

 

William Holland, Ph.D., Assistant Professor
Holland Lab
Research Interests: Our lab focuses on understanding the role of sphingolipids in metabolic disease. Modulating the flux of these lipids can have profound influences on glucose homeostasis, energy homeostasis, cell survival, and cancer biology.

 

Jay Horton, M.D., Professor
Horton Lab
Research Interests: Hepatic steatosis; lipid metabolism

 

Ming-Chang Hu, M.D., Ph.D., Associate Professor
Hu Lab
Research Interests: Abnormal mineral metabolism and dysregulation of Klotho/FGF23 axis related to acute kidney injury and chronic kidney disease, and to the complications in kidney diseases

 

Chou-Long Huang, M.D., Ph.D., Professor
Huang Lab
Research Interests: Biology of the WNK kinase cascade and the anti-aging protein Klotho, human (genetic) diseases caused by ion channel disorders, ion channel physiology, biophysics, and signaling mechanisms of ion channel regulation

 

Kristine E. Kamm, Ph.D., Professor
Kamm-Stull Lab
Research Interests: Muscle physiology; regulation of contractile and motile processes in smooth- and non-muscle cells

 

James Kim, M.D., Ph.D., Assistant Professor
Kim Lab
Research Interests: Cancer biology, lung cancer, developmental pathways, hedgehog signaling pathway, Wnt signaling pathway, tumor-stromal interactions, tumor microenvironment

 

W. Lee Kraus, Ph.D., Professor
Kraus Lab
Research Interests: Cellular signaling, gene regulation, and epigenetic control in the chromatin environment of the nucleus. Biological systems include: reproduction, cancer, inflammation, adipogenesis, stem cells, differentiation.

 

Lu Q. Le, M.D., Ph.D., Associate Professor
Le Lab
Research Interests: Tumor cell of origin; roles of tumor microenvironment in cancer development; cellular and molecular mechanisms of neurofibromatosis; stem cell and cancer biology

 

Guosheng Liang, Ph.D., Associate Professor
Liang Lab
Research Interests: Cholesterol homeostasis; metabolic diseases such as obesity and diabetes; transcriptional regulation

 

Mala Mahendroo, Ph.D., Professor
Mahendroo Lab
Research Interests: Parturition (the process of labor); cervical ripening; male and female reproductive biology

 

Pradeep Mammen, M.D., Associate Professor
Research Interests: Internal Medicine; treatment and management of patients with heart failure and the molecular mechanisms underlying this clinical entity. Currently, I run a molecular cardiology laboratory focused on understanding how regulation of the metabolic and redox states of muscle progenitor cells and myocytes can be modulated to serve as potential therapeutic targets for various cardiac and skeletal myopathies. Ultimately, the ability to selectively regulate the metabolic and redox states within these cells may provide opportunities for the development of novel therapeutic approaches to the treatment of patients with various myopathies.

 

David J. Mangelsdorf, Ph.D., Professor
Mangelsdorf/Kliewer Lab
Research Interests: Mechanism of action of nuclear hormone receptors; transcriptional regulation of lipid metabolism; role of retinoids and cancer

 

Ram Mani, Ph.D., Assistant Professor
Mani Lab
Research Interests: Epigenetic mechanisms underlying cancer progression; ETS gene fusions in prostate cancer; genomic rearrangements in cancer; transcriptional regulation in prostate cancer 

 

Steven McKnight, Ph.D., Professor
McKnight Lab
Research Interests: Subset of transcription factors that are gene-specific; regulation of transcription-factor function at a biochemical level with keen attention to biological relevance

 

Carole R. Mendelson, Ph.D., Professor
Mendelson Lab
Research Interests: Molecular mechanisms in tissue-specific, developmental, and hormonal regulation of eukaryotic gene expression

 

Chieko Mineo, Ph.D., Associate Professor
Shaul/Mineo Lab
Research Interests: Molecular basis of pathogenesis of antiphospholipid syndrome; role of Pentraxin C Reactive protein in metabolic syndrome; biology of lipoproteins and their receptors

 

Orson Moe, M.D., Professor
Moe Lab
Research Interests: Regulation of mammalian water and electrolyte homeostasis, including sodium, calcium, and acid-base metabolism and epithelial transport

 

Nancy Monson, Ph.D., Associate Professor
Monson Lab
Research Interests: Translational research; immune responses in autoimmune disease; the role of the immune system in neurological diseases of the brain

 

Lisa Monteggia, Ph.D., Professor
Monteggia Lab
Research Interests: Development of animal models for psychiatric diseases; growth factors and depression; role of MeCP2 in mediating autistic-like behavior; transcriptional repression in neurons

 
Nikhil Munshi

Nikhil Munshi, M.D., Ph.D., Assistant Professor
Munshi Lab
Research Interests: Cardiac development; transcriptional regulation; human genetics; arrhythmogenesis. The cardiac conduction system is an electrically coupled structure within the heart responsible for initiation and propagation of each heartbeat. Our lab is interested in elucidating the transcriptional mechanisms that dictate formation of the cardiac conduction system and its impact on the establishment of normal and pathological cardiac rhythms

 

Dayoung Oh, Ph.D., Assistant Professor
Research Interests: G protein-coupled receptors; Type 2 diabetes; Insulin resistance; Chronic inflammation; Development of novel therapeutic targets to treat Type 2 diabetes

 

Eric N. Olson, Ph.D., Professor
Olson Lab
Research Interests: Transcriptional control of cell differentiation; muscle development

 
Duojia Pan, Ph.D.

Duojia Pan, Ph.D., Professor
Pan Lab
Research Interests: Size-control mechanisms in development, regeneration, and cancer

 

Juan Pascual, M.D., Ph.D., Associate Professor
Research Interests: Animal and cellular models of neurogenetic disorders; synaptic transmission in experimental epilepsies; disorders of brain energy metabolism; developmental neurobiology; genotype:phenotype correlations in novel childhood encephalopathies; clinical pediatric neurology

 

Vishal Patel, M.D., Assistant Professor
Research Interests: Studying the roles of miRNAs in kidney development and kidney diseases

 

 

Beverly A. Rothermel, Ph.D., Associate Professor
Rothermel Lab
Research Interests: Internal Medicine; control of muscle remodeling during development and disease; circadian control of cardiac function and the role of RCAN1 (Down Syndrome Critical Region 1), a regulator of the calcium-dependent phosphatase calcineurin

 

Philipp Scherer, Ph.D., Professor
Scherer Lab
Research Interests: Adipocytes, angiogenesis, beta cells, breast cancer, intracellular protein trafficking

 

Philip W. Shaul, M.D., Professor
Shaul/Mineo/Umetani Lab
Research Interests: Endothelial cell biology, vascular development and disease; signaling molecules in endothelial cell caveolae/lipid rafts

 

 

James T. Stull, Ph.D., Professor
Kamm-Stull Lab
Research Interests: Myosin phosphorylation in the actin cytoskeleton and cell motility; modulation by signal-transduction pathways involving Ca2 and small GTP-dependent proteins

 

Philip J. Thomas, Ph.D., Professor
Thomas Lab
Research Interests: Function and structural development of ATP-dependent membrane proteins, including CFTR

 

 

Benjamin Tu, Ph.D., Associate Professor
Tu Lab
Research Interests: Metabolic cycles; mechanisms by which fundamental processes (e.g., cell growth and division, transcription, mitochondria homeostasis) are coupled to cellular metabolic state; yeast

 

Roger H. Unger, M.D., Professor
Unger Lab
Research Interests: Diabetes, obesity, lipotoxicity, internal medicine, islet physiology, and pathophysiology

 

Steven Vernino, M.D., Ph.D., Professor
Vernino Lab
Research Interests: Animal models of autoimmune autonomic neuropathy, serologic evaluation of patients with dysautonomia, disorders of neuromuscular hyperexcitability, paraneoplastic neurological syndromes

 

Yihong Wan, Ph.D., Associate Professor
Wan Lab
Research Interests: Transcriptional regulation of development, metabolism and cancer by nuclear receptors using the skeleton and the mammary gland as model systems

 

Richard Wang, M.D., Ph.D., Assistant Professor
Wang Lab
Research Interests: Regulation of glucose uptake; autophagy and skin cancer

 

Zhao Wang, Ph.D., Assistant Professor
Wang Lab
Research Interests: Heart failure, cardiac hypertrophy, diabetic cardiomyopathy, metabolic syndrome

 

Kevin W. Williams, Ph.D., Assistant Professor
Williams Lab
Research Interests: Understanding the cellular mechanisms that contribute to the coordinated control of food intake, body weight, and glucose homeostasis

 
Guanghua (Andy) Xiao, Ph.D.

Guanghua (Andy) Xiao, Ph.D., Associate Professor
Research Interests: Statistical methods in biomedical research, bioinformatics and computer software development, computer algorithm and database

 

Jin Ye, Ph.D., Associate Professor
Ye Lab
Research Interests: Host proteins required for hepatitis C virus replication; regulation of geranylgeranyl lipid homeostasis; regulated intramembrane proteolysis

 

Helen L. Yin, Ph.D., Professor
Yin Lab
Research Interests: Actin cytoskeletons of nonmuscle cells, including reorganization in response to extracellular signals; structure/function relationships of the gelsolin family of actin regulatory proteins

 

Qun Sophia Zang, Ph.D., Assistant Professor
Zang Lab
Research Interests: Mitochondria-targeted antioxidant therapy; mitochondrial signaling in sepsis-associated organ dysfunction; oxidative stress in sepsis/trauma-induced inflammation

 

Chengcheng (Alec) Zhang, Ph.D., Associate Professor
Zhang Lab
Research Interests: Mechanisms by which the cell fates of adult stem cells are regulated, and the interaction of adult stem cells and their in vivo microenvironment; ex vivo expansion of HSCs for cell therapy and gene therapy; the interplay between stem cells and cancer

 

Jeffrey M. Zigman, M.D., Ph.D., Professor
Zigman Lab
Research Interests: Identification of CNS targets of ghrelin action, the study of ghrelin cell physiology, functional neuroanatomy of the mammalian hypothalamus

 

Associate Members

These faculty members do not accept graduate students. They participate in teaching, co-mentoring, exam and dissertation committees, and all other program responsibilities.

 

Sandra L. Hofmann, M.D., Ph.D., Professor
Research Interests: Role of lipid-metabolizing enzymes in cell metabolism and signal transduction; covalent modification of proteins by the fatty acid palmitate; the study of enzymes that transfer the palmitate on and off modified proteins

 

Joyce Repa, Ph.D., Associate Professor
Research Interests: How nuclear receptors control the expression of ABC transport proteins and the consequences of this regulation on lipid balance with respect to atherosclerosis, diabetes, and brain physiology

 

Charles Rosenfeld, M.D., Professor
Research Interests: Cardiovascular adaptation during development and pregnancy; maturation and ontogeny of visceral and vascular smooth-muscle protein expression and function; regulation and function of angiotensin II receptor subtypes during development and pregnancy; mechanisms related to estrogen-induced vasodilation and modulation of uteroplacental blood flow in pregnancy

 

Rashmin C. Savani, M.D., Professor
Research Interests: Cell and mouse models to investigate the mechanisms of extracellular matrix regulation of lung development and injury, in particular, the interaction of hyaluronan (hyaluronic acid) with specific receptors to regulate cell migration in pulmonary vascular development, innate immunity, and inflammatory responses to injury

 

Douglas Strand, Ph.D., Assistant Professor
Research Interests: Tissue interactions, inflammation, metabolism, benign prostatic hyperplasia, stem cells, prostate cancer

 

Matthias Wolf, M.D., Assistant Professor
Research Interests: Renal physiology, calcium and magnesium homeostasis, electrophysiology, patch-clamp recording, urinary proteins, uromodulin, genetics of kidney disorders

 

Shin Yamazaki, Ph.D., Associate Professor
Research Interests: Circadian control of cell cycle

 

Xiaowei Zhan, Ph.D., Assistant Professor
Research Interests: Statistical genetics, statistical computation and association mapping using next generation sequencing technology

 

Andrew R. Zinn, M.D., Ph.D., Professor
Zinn Lab
Research Interests: Human genetic diseases, infertility, obesity, sex chromosome abnormalities