Integrative Biology Faculty

Yi Liu, Ph.D.
Program Chair
Liu Lab
Research Interests: Molecular mechanisms of circadian clocks 

Massimo Attanasio, M.D.
Assistant Professor
Research Interests:
Genetics of inherited kidney diseases, human genetics, molecular genetics, molecular biology

Ilya Bezprozvanny, Ph.D.
Bezprozvanny Lab
Research Interests: Neuronal calcium signaling and neurodegeneration; molecular mechanisms of Huntington's and Alzheimer's disease; calcium channels; synaptic transmission

Perry Bickel, M.D.
Associate Professor
Research Interests: Cellular lipid storage and utilization, specifically with respect to the function of perilipin family proteins

Rolf A. Brekken, Ph.D.
Associate Professor
Brekken Lab
Research Interests: Tumor-host interactions in pancreatic cancer as an avenue for the development of novel therapy; interplay between neoplastic genetic alterations, changes in the extracellular matrix, and angiogenesis in the development and progression of pancreatic cancer; gene therapy to restore SMAD4 expression in tumor cells; blocking VEGF-induced angiogenesis in tumors; function of the matricellular protein SPARC in tumor development

Michael S. Brown, M.D.
Brown/Goldstein Lab
Research Interests: Unraveling the mechanism by which the SREBP pathway regulates cholesterol metabolism at the molecular, cellular, and whole-body levels

Benjamin Chen, Ph.D.
Associate Professor
Chen Lab
Research Interests: DNA damage response; repair of DNA double-strand breaks

George N. DeMartino, Ph.D.
DeMartino Lab
Research Interests: Cell physiology; regulation of growth and atrophy; protein degradation; intracellular proteases; ubiquitin/proteasome pathway of protein degradation

Amelia J. Eisch, Ph.D.
Associate Professor
Eisch Lab
Research Interests: Adult mammalian neurogenesis and growth factors; cell-cycle analysis of adult neural stem cells in vivo; regulation of endogenous cell cycle proteins in psychiatric disorders such as addiction, depression, and Alzheimer’s disease; transgenic manipulation of adult mammalian neurogenesis

Joel K. Elmquist, D.V.M., Ph.D.
Elmquist Lab
Research Interests: Functional neuroanatomy of the mammalian hypothalamus

Andrew Feranchak, M.D.
Associate Professor
Feranchak Lab 
Research Interests: Hepatobiliary transport, mechanisms of bile formation, biophysical characterization of membrane ion channels, cell volume regulation, cholestatic liver disease

Christine Garcia, M.D., Ph.D.
Associate Professor
Garcia Lab
Research Interests: Genetic approaches to identifying primary determinants of lung disease

Joseph Garcia, M.D., D.Phil.
Associate Professor
Research Interests: Integrative biological studies of hypoxia-inducible transcription factors; identification of genetic factors controlling the cardiovascular-respiratory response to hypoxia

Laurent Gautron, Ph.D.
Assistant Professor
Gautron Lab

Dwight C. German, Ph.D.
German Lab
Research Interests: Mechanisms of neurodegeneration in neurological and psychiatric disorders, using human post-mortem tissue and animal models

Subroto Ghose, M.D., Ph.D.
Associate Professor
Ghose Lab
Research Interests: Neurobiology of schizophrenia using animal models, human post-mortem tissue, and human imaging approaches

Joseph L. Goldstein, M.D.
Brown/Goldstein Lab
Research Interests: Unraveling the mechanism by which the SREBP pathway regulates cholesterol metabolism at the molecular, cellular, and whole body levels

Frederick Grinnell, Ph.D.
Grinnell Lab
Research Interests: Cell signaling during wound repair; cell motility and contractility in wound contraction; MAP kinase and other signaling pathways regulating cellular reorganization of collagen matrices stimulated by platelet-derived growth factor, lysophosphatidic acid, and transforming growth factor beta

Rana Gupta, Ph.D.
Assistant Professor
Gupta Lab
Research Interests: Transcriptional control of fat cell development and adipose tissue expansion in obesity; manipulating the adipose lineage as a therapeutic treatment for metabolic disease

Joachim J. A. Herz, M.D.
Herz Lab
Research Interests: Molecular genetics; genetic manipulation of neuronal apoE receptors in mice; mechanisms of brain development, neurogenesis, and Alzheimer’s disease

Joseph A. Hill, M.D., Ph.D.
Hill Lab
Research Interests: Molecular signaling processes in cardiac hypertrophy and failure; mechanisms of structural, functional, and electrophysiological remodeling, using genetic and surgical mice models

Sandra L. Hofmann, M.D., Ph.D.
Research Interests: Role of lipid-metabolizing enzymes in cell metabolism and signal transduction; covalent modification of proteins by the fatty acid palmitate; the study of enzymes that transfer the palmitate on and off modified proteins

William Holland, Ph.D.
Assistant Professor
Holland Lab
Research Interests:Our lab focuses on understanding the role of sphingolipids in metabolic disease.  Modulating the flux of these lipids can have profound influences on glucose homeostasis, energy homeostasis, cell survival, and cancer biology.

Jay Horton, M.D.
Horton Lab
Research Interests: Hepatic steatosis; lipid metabolism

Ming-Chang Hu, M.D., Ph.D.
Assistant Professor
Research Interests: Abnormal mineral metabolism and dysregulation of Klotho/FGF23 axis related to acute kidney injury and chronic kidney disease, and to the complications in kidney diseases

Chou-Long Huang, M.D., Ph.D.
Huang Lab
Research Interests: Ion channels related to renal physiology and diseases, including renal potassium channel ROMK, epithelial calcium channel, and polycystic kidney disease protein related channels

Tae Hyun Hwang, Ph.D.
Assistant Professor
Hwang Lab
Research Interests: Bioinformatics, computational biology, network analysis, and next generation sequencing analysis

Kristine E. Kamm, Ph.D.
Kamm-Stull Lab
Research Interests: Muscle physiology; regulation of contractile and motile processes in smooth- and non-muscle cells

W. Lee Kraus, Ph.D.
Kraus Lab
Research Interests: Cellular signaling, gene regulation, and epigenetic control in the chromatin environment of the nucleus. Biological systems include: reproduction, cancer, inflammation, adipogenesis, stem cells, differentiation.

Lu Q. Le, M.D., Ph.D.
Assistant Professor
Le Lab
Research Interests: Tumor cell of origin; roles of tumor microenvironment in cancer development; cellular and molecular mechanisms of neurofibromatosis; stem cell and cancer biology

Guosheng Liang, Ph.D.
Associate Professor
Liang Lab
Research Interests: Cholesterol homeostasis; metabolic diseases such as obesity and diabetes; transcriptional regulation

Mala Mahendroo, Ph.D.
Associate Professor
Mahendroo Lab
Research Interests: Parturition (the process of labor); cervical ripening; male and female reproductive biology

Pradeep Mammen, M.D.
Associate Professor
Research Interests: Internal Medicine; treatment and management of patients with heart failure and the molecular mechanisms underlying this clinical entity. Currently, I run a molecular cardiology laboratory focused on understanding how regulation of the metabolic and redox states of muscle progenitor cells and myocytes can be modulated to serve as potential therapeutic targets for various cardiac and skeletal myopathies. Ultimately, the ability to selectively regulate the metabolic and redox states within these cells may provide opportunities for the development of novel therapeutic approaches to the treatment of patients with various myopathies.

David J. Mangelsdorf, Ph.D.
Mangelsdorf/Kliewer Lab
Research Interests: Mechanism of action of nuclear hormone receptors; transcriptional regulation of lipid metabolism; role of retinoids and cancer

Ram Mani, Ph.D.
Assistant Professor
Research Interests: Epigenetic mechanisms underlying cancer progression; ETS gene fusions in prostate cancer; Genomic rearrangements in cancer; Transcriptional regulation in prostate cancer

Steven McKnight, Ph.D.
McKnight Lab
Research Interests: Subset of transcription factors that are gene-specific; regulation of transcription-factor function at a biochemical level with keen attention to biological relevance

Carole R. Mendelson, Ph.D.
Mendelson Lab
Research Interests: Molecular mechanisms in tissue-specific, developmental, and hormonal regulation of eukaryotic gene expression

Chieko Mineo, Ph.D.
Associate Professor
Shaul/Mineo Lab
Research Interests: Molecular basis of pathogenesis of antiphospholipid syndrome; role of Pentraxin C Reactive protein in metabolic syndrome; biology of lipoproteins and their receptors

Orson Moe, M.D.
Moe Lab
Research Interests: Regulation of mammalian water and electrolyte homeostasis, including sodium, calcium, and acid-base metabolism and epithelial transport

Nancy Monson, Ph.D.
Associate Professor
Monson Lab
Research Interests: Translational research; immune responses in autoimmune disease; the role of the immune system in neurological diseases of the brain

Lisa Monteggia, Ph.D.
Monteggia Lab
Research Interests: Development of animal models for psychiatric diseases; growth factors and depression; role of MeCP2 in mediating autistic-like behavior; transcriptional repression in neurons

Nikhil Munshi, M.D., Ph.D.
Assistant Professor
Munshi Lab
Research Interests: Cardiac development; transcriptional regulation; human genetics; arrhythmogenesis. The cardiac conduction system is an electrically coupled structure within the heart responsible for initiation and propagation of each heartbeat.  Our lab is interested in elucidating the transcriptional mechanisms that dictate formation of the cardiac conduction system and its impact on the establishment of normal and pathological cardiac rhythms

Eric N. Olson, Ph.D.
Olson Lab
Research Interests: Transcriptional control of cell differentiation; muscle development

Juan Pascual, M.D., Ph.D.
Associate Professor
Research Interests: Animal and cellular models of neurogenetic disorders; synaptic transmission in experimental epilepsies; disorders of brain energy metabolism; developmental neurobiology; genotype:phenotype correlations in novel childhood encephalopathies; clinical pediatric neurology

Vishal Patel, M.D.
Assistant Professor
Research Interests: Studying the roles of miRNAs in kidney development and kidney diseases

Joyce Repa, Ph.D.
Associate Professor
Research Interests: How nuclear receptors control the expression of ABC transport proteins and the consequences of this regulation on lipid balance with respect to atherosclerosis, diabetes, and brain physiology

Aylin Rodan, M.D., Ph.D.
Assistant Professor
Rodan Lab 
Research Interests: Ion transport; renal physiology; Drosophila melanogaster; Malpighian tubule; kinases

Charles Rosenfeld, M.D.
Research Interests: Cardiovascular adaptation during development and pregnancy; maturation and ontogeny of visceral and vascular smooth-muscle protein expression and function; regulation and function of angiotensin II receptor subtypes during development and pregnancy; mechanisms related to estrogen-induced vasodilation and modulation of uteroplacental blood flow in pregnancy

Beverly A. Rothermel, Ph.D.
Associate Professor
Rothermel Lab
Research Interests: Internal Medicine; control of muscle remodeling during development and disease; circadian control of cardiac function and the role of RCAN1 (Down Syndrome Critical Region 1), a regulator of the calcium-dependent phosphatase calcineurin

Rashmin C. Savani, M.D.
Research Interests: Cell and mouse models to investigate the mechanisms of extracellular matrix regulation of lung development and injury, in particular, the interaction of hyaluronan (hyaluronic acid) with specific receptors to regulate cell migration in pulmonary vascular development, innate immunity, and inflammatory responses to injury

Philipp Scherer, Ph.D.
Scherer Lab
Research Interests: Identification and physiological characterization of novel secretory proteins that serve as potential links between the adipocyte and the processes of whole body energy homeostasis, inflammation, and cancer, thereby defining novel targets for pharmacological intervention and further defining the role of adipose tissue as an endocrine organ

Philip W. Shaul, M.D.
Shaul/Mineo/Umentani Lab
Research Interests: Endothelial cell biology, vascular development and disease; signaling molecules in endothelial cell caveolae/lipid rafts

Rhonda F. Souza, M.D.
Research Interests: Internal Medicine/VA Medical Center;  investigate the molecular mechanisms involved in the development and neoplastic progression of Barrett’s esophagus, focusing on the intracellular signaling mechanisms and biologic relevance of acid and/or bile acid exposure, the components of reflux, on Barrett’s esophagus using animal models, cell culture, and human biopsy tissues

James T. Stull, Ph.D.
Kamm-Stull Lab
Research Interests: Myosin phosphorylation in the actin cytoskeleton and cell motility; modulation by signal-transduction pathways involving Ca2 and small GTP-dependent proteins

Philip J. Thomas, Ph.D.
Thomas Lab
Research Interests: Function and structural development of ATP-dependent membrane proteins, including CFTR

Madhukar H. Trivedi, M.D.
Research Interests:  

Benjamin Tu, Ph.D.
Associate Professor
Tu Lab
Research Interests: Metabolic cycles; mechanisms by which fundamental processes (e.g., cell growth and division, transcription, mitochondria homeostasis) are coupled to cellular metabolic state; yeast

Roger H. Unger, M.D.
Unger Lab
Research Interests: Diabetes, obesity, lipotoxicity, internal medicine, islet physiology, and pathophysiology

Steven Vernino, M.D., Ph.D.
Vernino Lab
Research Interests: Animal models of autoimmune autonomic neuropathy, serologic evaluation of patients with dysautonomia, disorders of neuromuscular hyperexcitability, paraneoplastic neurological syndromes

Yihong Wan, Ph.D.
Assistant Professor
Wan Lab
Research Interests: Transcriptional regulation of development, metabolism and cancer by nuclear receptors using the skeleton and the mammary gland as model systems

Richard Wang, M.D., Ph.D.
Assistant Professor
Research Interests: Regulation of glucose uptake; autophagy and skin cancer

Kevin W. Williams, Ph.D.
Assistant Professor
Williams Lab
Research Interests: Understanding the cellular mechanisms that contribute to the coordinated control of food intake, body weight, and glucose homeostasis

Guanghua (Andy) Xiao, Ph.D.
Associate Professor
Research Interests: Statistical methods in biomedical research, bioinformatics and computer software development, computer algorithm and database

Hiromi Yanagisawa, M.D., Ph.D.
Associate Professor
H. Yanagisawa Lab
Research Interests: Molecular components of the vascular wall during development and disease

Masashi Yanagisawa, M.D., Ph.D.
M. Yanagisawa Lab
Research Interests: Identification and characterization of new signaling molecules that regulate vital functions such as sleep, appetite, and blood pressure

Jin Ye, Ph.D.
Associate Professor
Ye Lab
Research Interests: Host proteins required for hepatitis C virus replication; regulation of geranylgeranyl lipid homeostasis; regulated intramembrane proteolysis

Helen L. Yin, Ph.D.
Yin Lab
Research Interests: Actin cytoskeletons of nonmuscle cells, including reorganization in response to extracellular signals; structure/function relationships of the gelsolin family of actin regulatory proteins

Qun Sophia Zang, Ph.D.
Assistant Professor
Zang Lab
Research Interests: Mitochondria-targeted antioxidant therapy; Mitochondrial signaling in sepsis-associated organ dysfunction; Oxidative stress in sepsis/trauma-induced inflammation

Chengcheng (Alec) Zhang
Associate Professor 
Zhang Lab
Research Interests: Mechanisms by which the cell fates of adult stem cells are regulated, and the interaction of adult stem cells and their in vivo microenvironment; ex vivo expansion of HSCs for cell therapy and gene therapy; the interplay between stem cells and cancer

Jeffrey M. Zigman, M.D., Ph.D.
Associate Professor
Zigman Lab
Research Interests: Identification of CNS targets of ghrelin action, the study of ghrelin cell physiology, functional neuroanatomy of the mammalian hypothalamus

Andrew R. Zinn, M.D., Ph.D.
Zinn Lab
Research Interests: Human genetic diseases, infertility, obesity, sex chromosome abnormalities

Associate Members

These faculty members do not accept graduate students. They participate in teaching, co-mentoring, exam and dissertation committees, and all other program responsibilities.

Shin Yamazaki, Ph.D.
Research Interests: Circadian control of cell cycle

Xiaowei Zhan, Ph.D.
Research Interests: Statistical genetics, statistical computation and association mapping using next generation sequencing technology