Postdoctoral Training Opportunities

UT Southwestern Medical Center is committed to an educational and working environment that provides equal opportunity to all members of the University community. In accordance with federal and state law, the University prohibits unlawful discrimination, including harassment, on the basis of: race; color; religion; national origin; gender, including sexual harassment; age; disability; citizenship; and veteran status. In addition, it is UT Southwestern policy to prohibit discrimination on the basis of sexual orientation, gender identity, or gender expression.

Advanced Imaging Research Center Hematology Oncology, Internal Medicine Pathology
Biochemistry Human Growth and Development, Eugene McDermott Center
Pediatrics
Biophysics Hypertension, Internal Medicine Pharmacology
Cancer, Simmons Cancer Center Immunology Physiology
Cardiology, Internal Medicine Infectious Diseases, Internal Medicine Plastic Surgery
Cardiothoracic Surgery Microbiology Psychiatry
Cell Biology Mineral Metabolism, Internal Medicine Pulmonary, Internal Medicine
Center for Human Nutrition Molecular Biology
Radiation Oncology
Children's Research Institute at UT Southwestern Molecular Genetics
Radiology
Clinical Sciences
Nephrology, Internal Medicine Reproductive Biology, Cecil H. and Ida Green Center
Dermatology Neurology and Neurotherapeutics Surgery
Developmental Biology Neuroscience Systems Biology, Cecil H. and Ida Green Center
Digestive and Liver Diseases, Internal Medicine Obstetrics & Gynecology Therapeutic Oncology Research, Hamon Center
Endocrinology Ophthalmology Urology
Genetics of Host Defense Center
Otolaryngology - Head & Neck Surgery

Advanced Imaging Research Center

Intermediary Metabolism In Vivo (377)

A postdoctoral position is available in the laboratory of Eunsook Jin, Ph.D., in the Advanced Imaging Research Center of UT Southwestern Medical Center to study metabolism. Our laboratory has several exciting projects related to hepatic oxidative stress and antioxidant defense, liver toxicity caused by acetaminophen, intermediary metabolism in skeletal muscles, insulin resistance and obesity. We use rodent models in many studies, but we are actively involved in clinical researches, too. Stable isotopes and NMR are major tools in our lab.
Candidates must hold a Ph.D. and/or M.D. degree. Experience in metabolism, biology, biochemistry, medicine or relevant field leading to publication in peer-reviewed journals is recommended.
Interested individuals should send a CV, statement of interests, and a list of three references to:

Eunsook Jin, Ph.D., D.D.S.
UT Southwestern Medical Center
5323 Harry Hines Blvd.
Dallas, TX 75390-8568
eunsook.jin@utsouthwestern.edu

Biochemistry, Department of

Transcriptional Mechanisms in Reproductive Biology (370)

A postdoctoral position is available in the laboratory of Carole Mendelson, Ph.D, in the Department of Biochemistry to perform studies in female reproductive biology with emphasis on the transcriptional mechanisms involved in the maintenance of pregnancy and the initiation of labor and in placental biology. The regulatory roles of nuclear receptors, coregulators and chromatin modifications and their modulation by hormones and microRNAs will be emphasized. The research involves isolation and characterization of transcription factors, analysis of DNA-protein interactions and epigenetic modifications, primary cell culture, and characterization of mouse models. Candidates must hold a Ph.D. and/or M.D. degree. Experience in molecular biology and biochemistry is preferred.

Interested individuals should send a CV, statement of interests, and a list of three references to:
Carole R. Mendelson, Ph.D.
Department of Biochemistry
University of Texas Southwestern Medical Center
5323 Harry Hines Blvd.
Dallas, TX 75390-9038
Phone: 214-648-2944
carole.mendelson@utsouthwestern.edu

Cancer, Simmons Cancer Center

Cancer Immunotherapy (372)

A postdoctoral position is available in the laboratory of Kiyoshi Ariizumi, Ph.D., in the Department of Dermatology to study cancer immunotherapy using immune checkpoint blockade. Our laboratory has several exciting projects related to the cancer-promoting capacity of myeloid-derived suppressor cells induced in cancer patients. Our objectives are to understand the molecular and cellular mechanisms of the suppressor cells in promoting cancer growth and metastasis and to develop a new modality for treating cancer patients.
Candidates must hold a Ph.D. and/or M.D. degree. Experience in immunology and/or molecular biology leading to publication in peer-reviewed journals is recommended. Interested individuals should send a CV, short statement of interests, and a list of three references to:

Kiyoshi Ariizumi, Ph.D.
Associate Professor
UT Southwestern Medical Center
5323 Harry Hines Blvd.
Dallas, TX 75390-9069
kiyoshi.ariizumi@utsouthwestern.edu

Small Molecule Inhibitors for Cancer Therapy (371)

A postdoctoral position is available for a highly-motivated scholar to develop small molecule inhibitors for cancer therapy. The projects are focused on (1) biochemical and/or cellular assay development to support discovery of new small molecule inhibitors of cancer-related protein targets with emphasis on kinases and KRAS and (2) structure-guided optimization of lead compounds. The successful candidate will have the opportunity to be part of a collaborative team consisting of medicinal chemists, analytical biochemists and cancer biologists from several collaborating institutions. The ultimate goal is to develop compounds with activity in cancer models with the potential to become clinical therapeutics. For more information about the research program, please see the Westover Lab

Candidates must have a Ph.D. in biophysics, biochemistry, chemistry, chemical biology, cancer biology or a related field. The candidate should also have experience with protein biochemistry and biophysical methods. Experience with x-ray crystallography is preferred. Applicants must have at least one first-author publication in a peer-reviewed journal. Interested candidates should send a CV, statement of research interests, and the names of three references to:

Ken Westover, M.D., Ph.D.
5323 Harry Hines Blvd.
Dallas, TX 75390-9183
kenneth.westover@utsouthwestern.edu

Molecular Mechanisms Regulating Tumor Maintenance (358)

The Division of Hematology/Oncology and Simmons Cancer Center of UT Southwestern Medical Center are seeking two postdoctoral positions in the laboratory of Pier Paolo Scaglioni, M.D.

Areas of interest include:

  • Cancer Metabolism: Characterization of the role of mutant KRAS in reprogramming lipid biogenesis in lung cancer.
  • Cancer maintenance: Identification of the mechanisms that mediate the maintenance of mutant KRAS lung cancer. 
  • Regulation of oncogenic networks: Study of the role of the SUMO E3 ligase PIAS1 in the regulation of PML nuclear bodies and c-MYC.

These research topics will be addressed with a combination of molecular/cellular biology techniques and mouse cancer models.

Position Requirements: Candidates must hold an M.D. and/or a Ph.D. degree. Experience in the field of cellular/cancer biology leading to publication in peer-reviewed journals is recommended.

Interested individuals should send the following information:

  • A statement of interest explaining why the candidate is interested in the position and how the position might further the candidate’s career goals. 
  • An updated CV.
  • Names and contact information of three references.

Pier Paolo Scaglioni, M.D.
Assistant Professor
UT Southwestern Medical Center
5323 Harry Hines Blvd.
Dallas, TX 75390-8852
pier.scaglioni@utsouthwestern.edu
Scaglioni Lab

Bioinformatics, Genomics and Personalized Medicine in Kidney Cancer (337)

A postdoctoral position is available for a highly-motivated scholar to work in the area of genomics and personalized medicine in kidney cancer. The project is focused on integrating high-throughput data from next-generation sequencing, gene expression, and other genetic and epigenetic analyses using clinical samples and pre-clinical models. The successful candidate will have the opportunity to be part of a team made up of researchers, physicians and clinical geneticists that cares for patients with kidney cancer and will be involved in the evaluation of personalized patient cancer genomes. The ultimate goal is to leverage understanding of the molecular genetics and biology of kidney cancer to improve patient treatments. For more information about the research program, please see the Brugarolas Lab.

Candidates must have a Ph.D. in statistical genetics, bioinformatics, computer science, or a related field. The candidate should also have programming experience using Python, Perl, Java, or C/C++ and be familiar with tools such as R/Bioconductor or Matlab. A track record of productivity is essential. Successful applicants will have the opportunity to work in a translational research program spanning from molecular genetics to the clinic.

Interested candidates should send a CV, statement of research interests, and the names of three references to:
James Brugarolas, M.D., Ph.D.
5323 Harry Hines Blvd.
Dallas, TX 75390-9133
james.brugarolas@utsouthwestern.edu

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Cell Biology

Primary Cilia, Development, and Disease (373)

Two postdoctoral positions are available in our laboratory to study the role of ciliary signaling, particularly in the context of pathways regulating development of the limb, kidney, and brain.

The focus of the current research in our laboratory is to understand mechanisms of cellular signaling at the level of the primary cilia, and its relevance to human health and disease. The first cellular organelle to be described in biology, the primary cilium was long mistaken as a vestigial appendage. The primary cilia are now considered as vital sensory organelles for detection and transmission of a broad range of chemical and mechanical signals in most cells. Signaling mediated by the primary cilia plays fundamental roles in cellular differentiation, polarity and cell cycle control. We utilize a variety of biochemical, cell biological and reverse genetic approaches to understanding signaling mediated by cilia, and dissecting their role during normal development and carcinogenesis. A detailed description of current lab projects can be found at: http://www.utsouthwestern.edu/labs/mukhopadhyay/

Candidates must have a Ph.D. or M.D. /Ph.D., with less than three years of prior postdoctoral experience, and a demonstrated research record with at least one first author publication. Preference will be given to applicants with a strong background in cell and molecular biology, protein biochemistry, or mouse genetics.

Please email me (saikat.mukhopadhyay@utsouthwestern.edu) a copy of your current curriculum vitae, contact information for references, and a cover letter highlighting your prospective research plan.

Mechanisms of cilium-generated signaling (342)

A postdoctoral research position is open in the laboratory of William J. Snell, Ph.D., in the Department of Cell Biology at UT Southwestern Medical Center to study cellular and molecular mechanisms of cilium-generated signaling using the green alga Chlamydomonas as a model system. The primary cilium is well established as a key sensory and signaling organelle that is essential for development and homeostasis. Disruption of ciliary structure/function in humans leads to multiple disorders collectively termed the ciliopathies. Attesting to the ancient function of the organelle in sensory transduction, Chlamydomonas uses its two flagella/cilia for signaling during sexual reproduction.

Chlamydomonas offers several advantages as a system for studying cilium-generated signaling and regulation of the protein composition of the ciliary membrane. In addition to being able to use genetic, molecular biological, and ultrastructural approaches, it is particularly simple to isolate cilia from Chlamydomonas in quantities sufficient for biochemical studies. We have several ongoing projects, but the project a candidate works on will be arrived at based on specific interests and background. Applicants must have a Ph.D. and research training appropriate for our system. To apply, please email a copy of your resume, contact information for at least 3 referees, and a cover letter outlining your research interests. Visit the Snell Lab to learn more about our research.

William J. Snell, Ph.D.
Department of Cell Biology
University of Texas Southwestern Medical Center
6000 Harry Hines Blvd.
Dallas, TX 75390-9039
Phone: 214-648-3966
william.snell@utsouthwestern.edu

Children's Research Institute at UT Southwestern

Functional Cancer Epigenomics (355)

A postdoctoral position is available in the laboratory of Jian Xu, Ph.D., in the Children’s Research Institute at UT Southwestern Medical Center to study the functional genomics of stem cells and cancer. Our laboratory focuses on the intersection of transcriptional control with stem cell biology, hematopoiesis and cancer. We employ epigenetics, functional genomics, genome editing, biochemistry, and mouse genetics to define epigenetic and genetic programs that control blood stem cell development, and how these processes go awry in cancer progression. The Xu lab at UTSW brings together enthusiastic scientists with diverse backgrounds, and provides a wide range of perspectives in a multi-disciplinary and collaborative team setting.

The successful candidate must hold a Ph.D. and/or M.D. degree with a strong background in molecular biology, genetics, biochemistry, or a related field. The ideal candidate will exhibit independence, flexibility, and creativity with a record of scientific productivity. Previous experience in epigenetics, cancer genomics, bioinformatics, and/or mouse models is strongly preferred.

To apply: please submit CV, a short summary of research interest and experience, and a list of three references to:

Jian Xu, Ph.D.
UT Southwestern Medical Center
5323 Harry Hines Blvd.
Dallas, TX 75390-8502
jian.xu@utsouthwestern.edu
Children's Research Institute at UT Southwestern

Dermatology, Department of

Pathogenesis of Non-Melanoma Skin Cancer (375)

A postdoctoral scholar position is available in the laboratory of Richard Wang, M.D., Ph.D., in the Department of Dermatology. The position will be focused on the pathogenesis of non-melanoma skin cancer with a specific emphasis on the roles of glucose transport /metabolism and autophagy in tumor development.

Candidates must have a Ph.D. or M.D./Ph.D. in the biological sciences and preferably fluent in English, strong written and oral communication skills, and a skill set that includes: molecular cloning including successful application of shRNA and CRISPR/Cas9 technologies, immunoprecipitation, immunoblotting, protein biochemistry, mammalian cell culture, viral transduction, microscopy, and mouse work.

Candidates with at least one first-authored publication in a peer-reviewed journal and have an ability to write manuscripts and fellowship grant applications are encouraged to apply. Qualified applicants should send a CV and three letters of recommendation to:

Elizabeth Edwards
Department Administrator
Department of Dermatology
UT Southwestern Medical Center
5323 Harry Hines Blvd.
Dallas, TX 75390-9069
Fax: 214-648-5552
elizabeth.edwards@utsouthwestern.edu 

Developmental Biology

Bioinformatics, Genomics, and Personalized Medicine in Kidney Cancer (337)

A postdoctoral position is available for a highly-motivated scholar to work in the area of genomics and personalized medicine in kidney cancer. The project is focused on integrating high-throughput data from next-generation sequencing, gene expression, and other genetic and epigenetic analyses using clinical samples and pre-clinical models. The successful candidate will have the opportunity to be part of a team made up of researchers, physicians and clinical geneticists that cares for patients with kidney cancer and will be involved in the evaluation of personalized patient cancer genomes. The ultimate goal is to leverage understanding of the molecular genetics and biology of kidney cancer to improve patient treatments. For more information about the research program, please see the Brugarolas Lab website

Candidates must have a Ph.D. in statistical genetics, bioinformatics, computer science, or a related field. The candidate should also have programming experience using Python, Perl, Java, or C/C++ and be familiar with tools such as R/Bioconductor or Matlab. A track record of productivity is essential. Successful applicants will have the opportunity to work in a translational research program spanning from molecular genetics to the clinic. 

Interested candidates should send a CV, statement of research interests and the names of three references to:
James Brugarolas, M.D., Ph.D.
5323 Harry Hines Blvd.
Dallas, TX 75390-9133
james.brugarolas@utsouthwestern.edu

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Hematology Oncology, Internal Medicine

Molecular Mechanisms Regulating Tumor Maintenance (358)

The Division of Hematology Oncology and Simmons Cancer Center of UT Southwestern Medical Center are seeking two postdoctoral positions in the laboratory of Pier Paolo Scaglioni, M.D.

Areas of interest include:

  • Cancer Metabolism: Characterization of the role of mutant KRAS in reprogramming lipid biogenesis in lung cancer.
  • Cancer maintenance: Identification of the mechanisms that mediate the maintenance of mutant KRAS lung cancer. 
  • Regulation of oncogenic networks: Study of the role of the SUMO E3 ligase PIAS1 in the regulation of PML nuclear bodies and c-MYC.

These research topics will be addressed with a combination of molecular/cellular biology techniques and mouse cancer models.

Position Requirements: Candidates must hold an M.D. and/or a Ph.D. degree. Experience in the field of cellular/cancer biology leading to publication in peer-reviewed journals is recommended.

Interested individuals should send the following information:

  • A statement of interest explaining why the candidate is interested in the position and how the position might further the candidate’s career goals. 
  • An updated CV.
  • Names and contact information of three references.

Pier Paolo Scaglioni, M.D.
Assistant Professor
UT Southwestern Medical Center
5323 Harry Hines Blvd. 
Dallas, TX 75390-8852
pier.scaglioni@utsouthwestern.edu
Scaglioni Lab

Infectious Diseases, Internal Medicine

Innate immunity and Autoimmune Diseases (352)

A postdoctoral position is available in the lab of Nan Yan, Ph.D., in the Department of Internal Medicine to study innate immunity and autoimmune diseases. Candidates must have a Ph.D. and/or M.D. degree. Candidates should also have strong molecular biology, microbiology, or immunology background with extensive mouse experience. Candidates should be highly motivated and have recent publications from previous work.

Please send curriculum vitae and three letters of reference by email to:

Nan Yan, Ph.D.
Department of Internal Medicine
Division of Infectious Diseases
University of Texas Southwestern Medical Center
nan.yan@utsouthwestern.edu
Nan Yan Lab

Microbiology, Department of

HIV Transcription Complexes (378)

A postdoctoral position is available in the laboratory of Iván D’Orso, Ph.D., in the Department of Microbiology. We are seeking a highly motivated individual to investigate the assembly and activation of HIV transcription complexes. To this end, we are using a multidisciplinary approach including cellular and molecular biology, protein biochemistry, virology and structural biology (see McNamara R et al, Cell Reports, 5, 1256-1268 (2013) and D’Orso I & Frankel AD. Nat. Struct. Mol. Biol. 17: 815-827 (2010)). This position will provide excellent training opportunities and networked environment since UTSW is equipped with state-of-the-art facilities to conduct cutting-edge experiments.

Candidates must hold a Ph.D. in biochemistry, molecular biology, or related fields, with a strong background in molecular biology, biochemistry, RNA biology and protein expression. Expertise in structural biology techniques would be a plus. The candidate should have a strong publication record in quality peer-reviewed journals, demonstrated creative thinking, be able to work independently and have the ability to work collaboratively in a team. Applicants should send a cover letter, CV, and names/contact information of 3 references to:

Iván D’Orso, Ph.D.
UT Southwestern Medical Center
5323 Harry Hines Blvd.
Dallas, TX 75390-9048
ivan.dorso@utsouthwestern.edu

Bacterial gene regulation and Lyme disease pathogenesis (341)

A postdoctoral position is available in the laboratory of Michael Norgard, Ph.D., in the Microbiology Department to study virulence gene regulation in Borrelia burgdorferi, the Lyme disease spirochete. Studies will focus on the RpoN (Sigma54)-RpoS alternative sigma factor regulatory cascade and, in particular, the role of BosR as an accessory molecule for pathway activation (see Z. Ouyang et al. 2010. BosR [BB0647] controls the RpoN-RpoS regulatory pathway and virulence expression in Borrelia burgdorferi by a novel DNA-binding mechanism. PLoS Pathogens 7: e1001272). The position offers the opportunity to conduct research in an attractive, dynamic research environment with outstanding resources. Candidates must have a Ph.D. with a background in bacterial genetics, gene regulation, bacterial pathogenesis, and molecular biology. Experience in spirochetology, animal models, and/or tick biology is preferred. Please send a CV and three letters of recommendation to:

Michael V. Norgard, Ph.D.
Chair, Department of Microbiology
UT Southwestern Medical Center
6000 Harry Hines Blvd.
Dallas, TX 75390-9048
michael.norgard@utsouthwestern.edu

Molecular Biology, Department of

Primary Cilia, Development, and Disease (373)

Two postdoctoral positions are available in our laboratory to study the role of ciliary signaling, particularly in the context of pathways regulating development of the limb, kidney, and brain.

The focus of the current research in our laboratory is to understand mechanisms of cellular signaling at the level of the primary cilia, and its relevance to human health and disease. The first cellular organelle to be described in biology, the primary cilium was long mistaken as a vestigial appendage. The primary cilia are now considered as vital sensory organelles for detection and transmission of a broad range of chemical and mechanical signals in most cells. Signaling mediated by the primary cilia plays fundamental roles in cellular differentiation, polarity and cell cycle control. We utilize a variety of biochemical, cell biological and reverse genetic approaches to understanding signaling mediated by cilia, and dissecting their role during normal development and carcinogenesis. A detailed description of current lab projects can be found on our lab website

Candidates must have a Ph.D. or M.D. /Ph.D., with less than three years of prior postdoctoral experience, and a demonstrated research record with at least one first author publication. Preference will be given to applicants with a strong background in cell and molecular biology, protein biochemistry, or mouse genetics.

Please email me (saikat.mukhopadhyay@utsouthwestern.edu) a copy of your current curriculum vitae, contact information for references, and a cover letter highlighting your prospective research plan.

Deciphering Molecular Mechanisms of Bacterial Pathogens (369)

A postdoctoral position is available in the laboratory of Kim Orth, Ph.D., in the Department of Molecular Biology at UT Southwestern. The Orth lab is interested in translating molecular mechanisms used by bacterial pathogens to manipulate the host signaling pathways during infection. By understanding the activity of individual virulence factors that are secreted by type III secretion systems, we will be able to understand the multifaceted approach used by the bacteria during infection. In addition, by understanding the molecular mechanisms used by a single secretion system, we will gain insight into the overall pathology observed in the infected host cell. As demonstrated by our past discoveries, we elucidate both the host cell targets for the bacterial effectors and the bacterial effector’s molecular activity using a variety of biochemical, genetic and microbiology techniques.
Details on our research interests and past publications can be found at the Orth Lab

The candidate must possess a Ph.D., and should be self-motivated with a long-term interest in academic science. Expertise in biochemistry is preferred, as new projects will require this type of knowledge. Salary will be competitive and commensurate with experience. Please send CV and contact information for three references to:

Kim Orth, Ph.D.
Department of Molecular Biology
UT Southwestern Medical Center
6000 Harry Hines Blvd
Dallas, TX 75390-9148
kim.orth@utsouthwestern.edu

Neurology, Department of

Cancer Biology and Signal Transduction (374)

A postdoctoral training position is available to study signal transduction in cancer at the Department of Neurology. Our laboratory focuses on the following major areas of research; 1) Receptor tyrosine kinase signaling in cancer, 2) How inflammatory signaling networks influence oncogenic signaling pathways and 3) Synthetic lethal interactions in receptor tyrosine kinase signaling. We are particularly interested in the biology of glioma and use an approach combining in vitro experimental systems, mouse models and translational studies using human glioma tissue.

Recent publications from our lab include Nat Commun. 2014 Dec 15; 5:5811. doi: 10.1038/ncomms6811., Oncogene. 2014 Aug 14;33(33):4253-64, Cell Reports. 2013 Aug 29;4(4):764-75, Oncogene. 2013 Dec. 23. doi: 10.1038/onc.2013.534. [Epub ahead of print].

The laboratory is located at the Dallas VA Medical Center, a major teaching hospital of UT Southwestern.

Candidates must hold a Ph.D. or M.D., and be highly motivated and hardworking with experience in molecular and cell biology including evidence of research accomplishment. Experience working with a mouse model of cancer is strongly preferred. Our laboratory offers the opportunity to conduct high quality research in a supportive environment.

Please email your CV, a statement of research interests, and the names of three references to:
amyn.habib@utsouthwestern.edu

Neurophysiology in Autism Spectrum Disorders (ASD) (367)

A postdoctoral position is available in the laboratory of Yukari Takarae, Ph.D., in the Department of Psychiatry at the Center for Autism and Developmental Disabilities (CADD). The applicant will join a highly productive and diverse group of clinicians and researchers at CADD and participate in research projects that investigate neurophysiology of sensory abnormalities in Autism Spectrum Disorders (ASD).

The candidates must hold a Ph.D. preferably in psychology, neuroscience, or a related field and should have extensive experience conducting human EEG/ERP studies (preferably with dense channel arrays) and a strong interest in disorders of neurodevelopment in general and ASD in particular. Candidates with experience with advanced data analytic techniques (e.g., blind source separation, topographic statistics) and programming in Matlab will be preferred.

Interested individuals should send a CV, statement of research background and interests, contacts of three references, and copies of relevant publications to:

Yukari Takarae, Ph.D.
Center for Autism and Developmental Disabilities 
UT Southwestern Medical Center
5323 Harry Hines Blvd.
Dallas, TX 75390-9086 (9-digit ZIP required for delivery)
yukari.takarae@utsouthwestern.edu

Obstetrics and Gynecology, Department of 

Signaling and Gene Regulation (364)

W. Lee Kraus, Ph.D., is currently seeking applicants with a Ph.D. degree for postdoctoral training in the laboratory of signaling and gene regulation within the Cecil H. and Ida Green Center for Reproductive Biology Sciences.

The research in the Kraus Lab covers a broad array of topics, including signaling, gene regulation, and genome function, especially in the areas of chromatin, transcription, epigenetics, RNA biology, and nuclear endpoints of cellular signaling pathways. We are interested in a wide variety of model systems and experimental approaches, including biochemistry, molecular biology, structural biology, animal models, genomics, proteomics, bioinformatics, and computational biology.

Projects in the lab are focused on signal-regulated transcription in the chromatin environment of the nucleus, with a focus on the estrogen and nuclear NAD+ signaling pathways, PARPs, and non-coding RNAs in mammalian biological systems (e.g., hormone signaling, inflammation, ES cell biology, adipogenesis, and metabolism).

Candidates should submit a CV or resume, brief statement of interests and accomplishments, and a list of three references in one .pdf or .doc file by email to lee.kraus@utsouthwestern.edu. Successful applicants will receive competitive pay and benefits commensurate with the applicant’s level of experience.

UT Southwestern provides a dynamic, collaborative, and integrative research and training environment with state-of-the-art facilities.

Gene Regulation (363)

The faculty in the gene regulation laboratories of the Cecil H. and Ida Green Center for Reproductive Biology Sciences are currently seeking applicants with a Ph.D. degree for an integrated and dynamic postdoctoral training program in gene regulation. Successful applicants can choose research projects with the faculty listed below.

The research programs in the faculty members’ laboratories cover a broad array of topics, including signaling, gene regulation, and genome function, especially in the areas of chromatin, transcription, epigenetics, RNA biology, and nuclear endpoints of cellular signaling pathways. We are interested in a wide variety of model systems and experimental approaches, including biochemistry, molecular biology, structural biology, animal models, genomics, proteomics, bioinformatics, and computational biology.

  • Xiaoying Bai, Ph.D.: Zebrafish and mammalian models to study the transcriptional mechanisms that regulate the differentiation of hematopoietic stem cells, as well as epigenetic regulation affecting Pol II elongation through chromatin.
  • Laura Banaszynski, Ph.D.: Role of histone variants in the establishment of chromatin states involved in cell specification during mammalian developmental processes, with a focus on non-coding elements in ES cells such as enhancers and repeat regions.
  • Gary Hon, Ph.D.: Mechanisms of enhancer-mediated gene regulation, especially how genetic and epigenetic dysregulation of regulatory elements contributes to disease. Our goal is to integrate genomic and bioinformatics approaches to build predictive models gene regulation.
  • W. Lee Kraus, Ph.D.: Signal-regulated transcription in the chromatin environment of the nucleus, with a focus on the estrogen and nuclear NAD+ signaling pathways, PARPs, and non-coding RNAs in mammalian biological systems (e.g., hormone signaling, inflammation, ES cell biology, adipogenesis, and metabolism).
  • Xin Liu, Ph.D.: Interplay between three-dimensional chromatin structures and eukaryotic transcription by RNA polymerase II, focusing on the molecular and biophysical basis of chromatin loop and heterochromatin formation during transcriptional regulation.
  • Yunsun Nam, Ph.D.: Mechanisms underlying gene regulation by non-coding RNAs, especially those pertinent to development and cancer. Biochemical and structural studies to determine the molecular basis of substrate recognition, catalysis, and regulation of microRNA biogenesis.

Candidates should submit a CV or resume, brief statement of interests and accomplishments, and a list of three references in one .pdf or .doc file by email to lee.kraus@utsouthwestern.edu.

The subject line should include the terms “Postdoctoral Training in Gene Regulation” and the body of the emails should indicate the laboratories of interest. Successful applicants will receive competitive pay and benefits commensurate with the applicant’s level of experience.

UT Southwestern provides a dynamic, collaborative, and integrative research and training environment with state-of-the-art facilities.

Ophthalmology, Department of 

Corneal Epithelial Cell and Molecular Biology (365)

A postdoctoral position is available in the laboratory of Danielle Robertson, O.D., Ph.D., in the Department of Ophthalmology at UT Southwestern Medical Center. Work in Dr. Robertson’s laboratory is focused on mechanisms regulating homeostasis in the corneal epithelium and how these mechanisms are altered in disease.

Candidates must hold a Ph.D./and or M.D. with a strong background in molecular and cellular biology and/or biochemistry. The candidate must be highly motivated and have extensive experience with cell culture, molecular biology, and contemporary imaging techniques. A strong publication record is recommended.

Interested individuals should send a C.V., statement of interests, and a list of three references to:

Danielle M. Robertson, O.D., Ph.D.
Department of Ophthalmology
5323 Harry Hines Blvd.
Dallas, TX 75390-9057
danielle.robertson@utsouthwestern.edu
Robertson Lab 

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Pathology, Department of

Neurodegenerative, Immunity and Allergic Disease (376)

A postdoctoral position is available in the laboratory of Dr. James Malter, in the Pathology Department of UT Southwestern Medical Center to study the function and regulation of Pin1, a cis-trans prolyl isomerase involved in cell cycle progression, neurodegenerative disease, immunity and allergic disease (see Sci Sig Mar 9;3(112):ra18; Nat Immunology 10:257-65, JI 190(10):4937-45).

Applicants must hold a Ph.D. and/or M.D. in the biological sciences or other related disciplines and have a strong publication record. Experience with cell and molecular biology, microscopy, and cell culture required.

Interested candidates should send a cover letter, CV, description of research accomplishment and three references to:

James Malter, M.D.
Professor and Chair
Department of Pathology
UT Southwestern Medical Center
5323 Harry Hines Blvd NB6.212
Dallas, TX 75235-9072
Email: James.Malter@utsouthwestern.edu

Prostate Cancer Epigenetics and Genomics (368)

Two postdoctoral positions are currently available in the Research Group of Ram Mani, Ph.D., in the Pathology Department. We are seeking highly motivated candidates with a background in cancer biology, epigenetics, chromatin biology, DNA repair and/or genomics. The research focus is in the area of prostate cancer epigenetics and genomics. We are interested in understanding the epigenetic signatures of prostate cancer development with an emphasis on mechanisms of treatment resistance. We are also interested in studying the molecules and pathways underlying the formation of genomic rearrangements in cancer, with a major focus on ETS gene fusions. We employ state of art molecular biology and cell biology tools, next-generation sequencing methods like ChIP-Seq, custom capture sequencing in addition to in vivo experiments to address these scientific questions. For additional information on our research, see Science (2009 #PMID: 19933109), Cancer Cell (2010 #PMID:20478527), Nature Reviews Genetics (2010 #PMID:21045868), Cancer Research (2011 #PMID:21676887).

Applicants must hold a Ph.D., and/or MD in biological sciences or other related disciplines and have a strong publication record. Experience with bioinformatics is a plus.

Interested candidates should send a cover letter, CV, description of research accomplishment and three letters of reference to:

Ram S. Mani, Ph.D.
Assistant Professor
Department of Pathology
UT Southwestern Medical Center
5323 Harry Hines Blvd.
Dallas, TX 75235-9072
ram.mani@utsouthwestern.edu

Bioinformatics at UT Southwestern (357)

The Pathology Department is recruiting for a postdoctoral candidate. The focus is on the analysis of complex datasets including: DNA-sequencing, RNA-sequencing, metabolomics, and drug sensitivity data. Specific emphasis will be placed on delineating the impact of specific pathways on disease progression and therapeutic response using data from clinically annotated tissue specimens and patient-derived models.

Ideal candidates should have experience with bioinformatics, a track record of leading projects to publication, and be creative in using computational methods to interrogate complex biological problems. Postdoctoral fellows will be expected to direct independent projects in a multi-disciplinary setting, assist in mentoring junior lab members, and apply for independent fellowship funding. A long-term goal of the project is to bring the research to clinical application and fellows will have the opportunity to directly contribute to clinical trial development and interactions with the multi-disciplinary teams in molecular oncology.

Requirements:
1. Ph.D. in a related discipline
2. Record of research accomplishment
3. Self-motivated with a positive attitude
4. Strong interpersonal skills

Interested individuals should send a CV, statement of interests, and a list of three references to:
Erik Knudsen, Ph.D.
UT Southwestern Medical Center
5323 Harry Hines Blvd.
Dallas, TX 75390-9072
erik.knudsen@utsouthwestern.edu
Attention:
linda.jones@utsuothwestern.edu

Neuronal Cell Death Research (353)

The Pathology Department at UT Southwestern Medical Center is recruiting for two postdoctoral positions to be filled January 2015 in the laboratory of Yingfei Wang, Ph.D., to study neuronal cell death after acute brain injury. We will use a combination of tools, including epigenomics, bioinformatics, proteomics, and mouse genetics, to study the molecular mechanism of PARP-1-dependent cell death (parthanatos) by focusing on the newly identified parthanatos-dependent AIF-associated nuclease (PAAN1) in acute brain injury. The project is supported by NIH grant. UTSW offers an excellent working environment and competitive benefits package.

Requirements: Candidates must have a Ph.D. or M.D./Ph.D. degree in biological sciences or other related disciplines. A strong background in molecular biology, biochemistry and animal models of global or focal ischemic stroke is desired. 

Interested individuals should send a cover letter with a brief description of research experience and interests, CV, and three supporting letters to: Yingfei Wang, Ph.D., yingfei.wang@utsouthwestern.edu.

Gene Regulation and Cancer Biology (354)

The Pathology Department at UT Southwestern Medical Center is recruiting for several postdoctoral positions expected to be filled in January 2015, in the laboratory of Weibo Luo, Ph.D., to study gene regulation by hypoxia-inducible factors in breast cancer (Cell 2011, 145(5):732-44; PNAS 2012, 109(49):E3367-76). We are particularly interested in understanding the crosstalk of oxygen homeostasis, epigenetics, and metabolism in breast cancer progression. The cutting-edge techniques including proteomics, next generation sequencing, and metabolomics are used in our studies. Our research is supported by NCI and CPRIT.

Requirements: We are seeking highly motivated candidates with a Ph.D. or M.D./Ph.D. Interested candidates must have 1) a strong background in biochemistry, molecular biology, and oncology, 2) a strong publication record, and 3) good communication skills. Experience with bioinformatics is a plus.

Interested individuals should send a cover letter, CV, and three reference letters via email to Weibo Luo, Ph.D., at weibo.luo@utsouthwestern.edu.

Pediatrics, Department of

Ion Channels Involved in Liver Transport (359)

The laboratory of Andrew Feranchak, M.D., has a position for a talented researcher at the level of postdoctoral research fellow. Studies will focus on ion channels involved in hepatobiliary transport in normal and cystic fibrosis models. This is an opportunity for a talented researcher to expand their skills in the study of epithelial cell biology, ion channel regulation, and imaging analysis.

Requirements: Ph.D. or M.D. (mandatory), experience with development of transgenic models, targeted gene knockdown, Cre/LoxP, CRISPR-Cas9 systems, molecular biology, and experience with cystic fibrosis mouse models.

Send cover letter, curriculum vitae, and names of 3 references to:
Darlene Anyzeski, Administrative Assistant,
darlene.anyzeski@utsouthwestern.edu

Andrew Feranchak, M.D.
UT Southwestern Medical School
5323 Harry Hines Blvd.
Dallas, TX 75390-9063
Phone: 214-648-3892
Fax: 214-648-2096
Feranchak Lab 

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Psychiatry, Department of

Molecular Biologist / Biochemist (356)

Fellow Research Associate position is available immediately in the lab of Saïd Kourrich, Ph.D., at UT Southwestern Medical Center. The applicant will join a highly collaborative research group that focuses on the relationships between drug-induced changes in synaptic/intrinsic excitability and the development of drug addiction. The successful applicant will investigate signaling pathways that contribute to drug-induced changes in specific voltage-gated ion channels. Experiments will involve a combination of in vitro (cell culture) and brain slice electrophysiology.

The successful candidate must hold a Ph.D. in cell biology, neurobiology, biology, or closely related field. Strong expertise in cell culture (primary neuronal or neuroblastoma lines) and immunocytochemistry are required. Experience in DNA constructs, cell transfection, and ligand-receptor binding assay would be appreciated. Experience in electrophysiological patch-clamp recordings is not required. To apply, send CV and names of three references directly to: said.kourrich@utsouthwestern.edu.

Said Kourrich, Ph.D.
Assistant Professor
UT Southwestern Medical Center
5323 Harry Hines Blvd.
Dallas, TX 75390-9070
Department: Psychiatry
Kourrich Lab 

Radiology, Department of

Novel MRI Approaches to Evaluate Tumor Growth (361)

In light of new grant funding from the Cancer Prevention Research Institute of Texas (CPRIT), we seek a highly motivated individual to pursue innovative oxygen sensitive MRI of prostate cancer at UT Southwestern Medical Center, Dallas, Texas.

Full-time postdoctoral research fellow position is immediately available in the Department of Radiology for an investigator to undertake development research related to pathophysiology of tumors. This CPRIT-supported research program is developing novel MRI approaches to evaluate tumor growth and response to therapy. In particular, we seek to develop hypoxia related biomarkers to predict radiation response.

The position requires a Ph.D. in physics, chemistry, biology, or a related field. Ideally, the individual will have skills in biological MRI. The position is part of the Laboratory for Prognostic Radiology. Primary investigations will use 4.7T small animal MRI and a newly installed Precision X-ray small animal irradiator. There will be opportunities to develop additional research initiatives related to vascular disrupting agents, optical and ultrasound imaging, 19F MRI, and clinical translation. There will be close interactions with investigators in Radiation Oncology. Competitive salary and benefits are on the NIH pay scale. Details of the program are available on the Mason Lab website.

Please send CV to:

Ralph P. Mason, Ph.D., CSci, CChem., FRSC
Professor
Department of Radiology
UT Southwestern Medical Center
5323 Harry Hines Blvd.
Dallas, TX 75390-9058
ralph.mason@utsouthwestern.edu

Development of Motion-Insensitive Volumetric MRI Techniques of the Abdomen (360)

Postdoctoral Scholar: Immediate opening for a postdoctoral scholar to undertake development research related to advanced magnetic resonance imaging (MRI), targeted at novel approaches for motion-insensitive acquisitions of the abdomen. In particular, we seek to develop free-breathing volumetric acquisitions for dynamic-contrast-enhanced imaging of the abdomen as well as validation of other qualitative and quantitative volumetric MRI acquisitions in the setting of physiologic motion. Research efforts will include MR pulse sequence design and reconstruction strategies combined with phantom experiments using an MRI-compatible motion platform, as well as MRI experiments in healthy and patient volunteers.

The ideal candidate must have an advanced degree (Ph.D. or equivalent), skills in biological MRI, and experience with MRI pulse sequence programming and MATLAB/IDL.

The position will be in the Translational Research Imaging Laboratory located in the Department of Radiology at UT Southwestern Medical Center.

Primary investigations will use state-of–the-art dual-transmit, whole-body, 3T MRI scanners. There will be opportunities to develop additional research initiatives related to body MRI at 3T and the 7T whole body scanner in the Advanced Imaging Research Center (AIRC). There will be close interactions with investigators in the Department of Radiology and AIRC.

Competitive salary and benefits are on the NIH pay scale.

Interested candidates should submit CV and 3 references to Ivan Pedrosa, M.D. For further information, please contact ivan.pedrosa@utsouthwestern.edu

Ivan Pedrosa, M.D.
UT Southwestern Medical Center
5323 Harry Hines Blvd.
Dallas, TX 75390-9085

Surgery, Department of 

One NIH-funded postdoctoral training position is available July 1, 2015, for 12-month appointments. M.D.s or Ph.D.s from accredited medical or graduate schools who are interested in developing investigative techniques to examine mechanisms by which traumatic injury, sepsis, and inflammation alter downstream organ function are eligible. M.D.s must have completed a minimum of two years of residency in surgery, pediatrics, or anesthesia.

Candidates should send their CV, a statement of goals and expectations, and two references by January 2, 2015, to:

Steven Wolf, M.D.
Program Director
UT Southwestern Medical Center
5323 Harry Hines Blvd.
Dallas, TX 75390-9031
Phone: 214-648-7200
ariza.sisavath@utsouthwestern.edu

Systems Biology, Cecil H. and Ida Green Center

Green Center for Systems Biology (362)

Two postdoctoral researcher positions are currently available in the Toprak Lab at the Cecil H. and Ida Green Comprehensive Center for Molecular, Computational, and Systems Biology at UT Southwestern Medical Center.

The Toprak Lab investigates genetic and molecular basis of phenotypic diversity observed in nature by using a range of methodologies such as whole genome sequencing, transcriptome analysis, fluidics, fluorescence, long-term evolution experiments, large-scale combinatorial mutagenesis, and computational methods. Toprak Lab develops and uses “aim-specific” fluidic and single molecule imaging technologies to tackle biological problems.

More information about the Toprak Lab.

Candidates must have a Ph.D. degree with training in bacteria and/or yeast genetics, biochemistry, biophysics, computational biology, bioinformatics, microfluidics, and mathematical modeling.

Please send your CV, a brief summary of research experience and a list of three references to:

Erdal Toprak, Ph.D.
Assistant Professor & Southwestern Medical Foundation Scholar in Biomedical Research 
Green Center for Systems Biology
UT Southwestern Medical Center
5323 Harry Hines Blvd.
Dallas, TX 75390-8597
Phone: 214-645-8134
Fax: 214-645-5965
erdal.toprak@utsouthwestern.edu


There are no opportunities currently posted for this department or center at this time.