Postdoctoral Training Opportunities

Advanced Imaging Research Center

Development of New Endogenous Contrast Mechanisms (228)

A full time postdoctoral researcher position is available in the Department of Radiology and Advanced Imaging Research Center at University of Texas Southwestern Medical Center. Research is focused on the development of new endogenous contrast mechanisms, with specific emphasis on CEST. The project will include development of new pulse sequences, image analysis and theoretical models development. The research will be conducted on the dual transmit whole body 3T Philips scanner. Additional research opportunities will be explored using 7T whole body human scanner or small animal Varian 7T or 9.4T systems. 

The position requires a PhD in physics, chemistry, biology or related field. The ideal candidate will have strong MRI or NMR background. Experience with pulse programming (such as Philips or Varian) is not mandatory, but would be an advantage.
Applicants are invited to send CV and the contact information of 2-3 references to Elena Vinogradov, PhD: elena.vinogradov@utsouthwestern.edu

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Department of Biochemistry

Differential Profiling of Ubiquitinome via Proteomics (212)

A postdoctoral position is available immediately to investigate dynamics of ubiquitinome and ubiquitin-like proteomes using modern proteomics technologies. A successful candidate will use a combination of advanced separation techniques such as 2D Gel Electrophoresis (2D-GE) and 2D chromatography in conjunction with advanced mass spectrometry techniques developed in our lab to define and study the dynamics of ubiquitinome. A candidate should be proficient in 2D-GE, chromatography and immunopurification methods. A PhD and asolid background in molecular biology is required. Candidates with strong quantitative skills and separation science backgrounds are most highly desired. Previous experience with mass spectrometry is not required but can be a plus. A candidate must be strong in communication and analytical skills, focused and motivated to succeed, and able to work as a team as well as independently. Salary is commensurate with qualifications and experience (based on UT Southwestern scale). The position will be initially available for one year, with the renewal (up to 4-5 years) based on the performance and funding availability. The successful candidate will be encouraged to apply for independent fellowships to gain independent programs for his/her future career path. Email a cover letter (1-2 pages) outlining your research interest and career goal, current curriculum vitae, and name and email address of three-four referees to:

Dr. Hamid Mirzaei
Assistant Professor of Biochemistry
Director of Proteomics Core Facility
CPRIT Cancer Research Scholar
Department of Biochemistry
T. Boone Pickens Biomedical Building
6001 Forest Park Road
Dallas, TX 75390-9050
Email: hamid.mirzaei@utsouthwestern.edu

Structure and Function of Mitochondrial Protein Kinases (197)

A postdoctoral position is available to conduct x-ray crystallography in the Department of Biochemistry at UT Southwestern Medical Center, Dallas, Texas.

The incumbent will investigate the structure and function of mitochondrial protein kinases (For references see: EMBO J. 24:1763, 2005; EMBO J. 25:5983, 2006; Structure 16:1849, 2008) and work with a multi-disciplinary team comprised of biochemists, synthetic chemists, pharmacologists and structural biologists to structure-based design and produce novel small-molecule inhibitors specific for these protein kinases. The inhibitors will be studied in cell culture and animal models as new strategies to metabolically target cancer, type 2 diabetes and disorders in branched-chain amino acid catabolism.

Applicants must have a PhD degree with training and first-author publications in X-ray crystallography.

Send CV with cover letter and names of three references to:

David Chuang, PhD
Professor
Department of Biochemistry
UT Southwestern Medical Center
5323 Harry Hines Blvd.
Dallas, Texas 75390-9038
Email: david.chuang@utsouthwestern.edu

UT Southwestern is an Equal Opportunity/Affirmative Action Employer.

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Harold C. Simmons Comprehensive Cancer Center  

Breast Cancer Metastasis (188)

A postdoctoral position is available immediately in the Simmons Cancer Center. The new postdoctoral fellow will investigate how tumor stem cells and the microenvironment induce breast cancer metastasis. These studies will employ advanced real-time imaging techniques, organotypic culture systems and animal models. 

A PhD or equivalent is required. Expertise with basic cell culture and molecular biology methods is necessary and experience working with mouse models is preferred.

Please send a CV and three letters of reference to:

Gray Pearson, PhD
Assistant Professor
Simmons Cancer Center
UT Southwestern Medical Center
6001 Forest Park Rd.
Dallas, TX 75390-8807
Email: gray.pearson@utsouthwestern.edu

UT Southwestern is an Equal Opportunity/Affirmative Action Employer.

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Cardiology, Department of Internal Medicine 

Hypoxia Signal Transduction in Mammals (198) 

One fully funded postdoctoral research position will be available to study hypoxia signal transduction in mammals. This project will use molecular, biochemical, cell culture, and transgenic mouse techniques.

Applicants must have a MD, PhD, or equivalent degree with a publication record in internationally recognized journals. Preference will be given to applicants with prior experience in HIF biology, hypoxia or environmental signaling, signal transduction, gene expression analysis, and protein biochemistry. Experience with mass spectrometry and HPLC chromatography sample preparation and analysis is highly desirable.

Interested candidates should email a cover letter, representative publications, and curriculum vitae with contact information for three references to the address listed below.

Joseph A. Garcia, MD, PhD
Department of Internal Medicine
Division of Molecular Cardiology
UT Southwestern Medical Center
5323 Harry Hines Blvd
Dallas, TX  75390-8573
Email: joseph.garcia@utsouthwestern.edu 

Blood Pressure Regulation (190)

A postdoctoral position is available which will focus on human integrative physiology involved in blood pressure regulation.

The position is funded by a T32 training grant from NIH for maximum of 2 years. Candidates must have an earned PhD and/or MD Grantor guidelines require candidates to be U.S. citizens or permanent residents. Experience in cardiovascular physiology would be useful. Salary is dependent on level of training and is competitive. 

Applicants should submit a C.V., including transcripts, list of publications, a description of their present research activity, and names of three references to:

Wanpen Vongpatanasin, MD
Department of Internal Medicine/Cardiology Division
UT Southwestern Medical Center
5323 Harry Hines Blvd.
Dallas, TX, 75390-8586
Phone: 214-648-2103
Email: wanpen.vongpatanasin@utsouthwestern.edu

Chemical Biology and Models of Cariogenesis, Neurogenesis, Diabetes & Cancer (187)

Several postdoctoral positions are available in the chemical biology laboratory of Dr. Jay Schneider in the Cardiology Division/Internal Medicine Dept. at UT Southwestern Medical Center in Dallas. Positions are funded by grants from AHA-DeHaan Cardiac Myogenesis Research Center, NIH-NHLBI Progenitor Cell Biology Consortium, Cancer Prevention and Research Institute of Texas and Lone Star Heart Sponsored Research Agreement.

The Schneider laboratory is recruiting postdoctoral candidates with broad-spectrum interests and expertise in four primary areas:

• Cardiogenesis and stem/progenitor-mediated heart repair
• Neural stem cell differentiation and adult hippocampal neurogenesis
• Obesity, diabetes mellitus and metabolism
• Cancer cell growth and differentiation

The principle that unifies these diverse areas is a collection of synthetic small-molecules obtained from a high throughput screen of the UT Southwestern chemical compound library. These pleiotropic small-molecules regulate gene expression in progenitor-like cells, both in culture models and, in some cases, in vivo, and have demonstrated activity in cardiogenesis, neurogenesis, diabetes mellitus and cancer cell models.

Projects immediately available involve preclinical testing of candidate small-molecule drugs for in vivo efficacy in mouse heart injury-repair models, adult neurogenesis, diabetes mellitus and cancer models, as well as molecular and cellular mechanistic studies directed towards target discovery. Experience in chemical biology – using novel small-molecule probe compounds to discover biological mechanisms – and pharmacology is highly desirable. Additionally, experience with stem/progenitor cell culture, including ES, iPS and neural stem cell culture is desirable.

Techniques employed in the laboratory include cell culture, reporter gene assays, protein blotting, Q-PCR, FACS, RNA micro-arrays, proteomics and bioinformatics. We employ a number of genetically modified mouse models to study native stem/progenitor cells in the adult heart and other tissues. Cardiac injury models include LAD-MI, TAB and doxorubicin cardiotoxicity.

A PhD is required in molecular or cellular biology, chemistry, pharmacology or related field. 

Relevant publications include:

• Sadek H., et al., 2008. Cardiogenic small molecules that enhance myocardial repair by stem cells. Proc. Natl. Acad. Sci. USA 105, 6063-6068. (http://www.ncbi.nlm.nih.gov/pubmed/18420817)
• Schneider, J.W., et al., 2008. Small-molecule activation of neuronal fate. Nature Chemical Biology 4, 408-410. (http://www.nature.com/nchembio/journal/v4/n7/abs/nchembio.95.html)
• Russell, J.R., et al., 2011. A dynamic Notch injury response activates epicardium and contributes to fibrosis-repair. Circulation Research 108: 51-59.  (http://www.ncbi.nlm.nih.gov/pubmed/21106942) and see commentary on this paper in: Rentschler, S., Epstein, J.A. 2011. Kicking the epicardium up a Notch. Circulation Research 108: 6-8. (http://www.ncbi.nlm.nih.gov/pubmed/21212389)

Contact: Jay Schneider, MD, PhD
Internal Medicine/Cardiology
5323 Harry Hines Blvd.
Dallas, TX  75390-8573
Email: jay.schneider@utsouthwestern.edu

UT Southwestern is an Equal Opportunity/Affirmative Action Employer.

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Department of Cell Biology

There are no positions available at this time.
UT Southwestern is an Equal Opportunity/Affirmative Action Employer.

Center for Human Nutrition

There are no positions available at this time.
UT Southwestern is an Equal Opportunity/Affirmative Action Employer.

Department of Clinical Sciences

There are no positions available at this time.
UT Southwestern is an Equal Opportunity/Affirmative Action Employer.

Computational and Systems Biology 

There are no positions available at this time.
UT Southwestern is an Equal Opportunity/Affirmative Action Employer.

Department of Dermatology

There are no positions available at this time.
UT Southwestern is an Equal Opportunity/Affirmative Action Employer.

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Department of Developmental Biology

Molecular Mechanisms of Gliogenesis (180)

A postdoctoral fellow position is open for individuals with an interest in the transcriptional and epigenetic mechanisms of neuroglial subtype development and differentiation in the vertebrate nervous systems including miRNA and chromatin remodeling control.

See recent publications from our laboratory:

• CELL, 109: 75-86
• Nat. Neurosci. 4: 973-974
• Nat. Neurosci. 12: 829-38
• i. 12: 1398-406
• NEURON 25:17–329; NEURON, 65:612-626.

A PhD and publications in the areas of Molecular Biology, Biochemistry or Neuroscience are required. The successful applicant will be self-motivated and use state-of-the-art technology and genetic mouse models to unravel mechanisms of glial differentiation and myelinogenesis.

Please send your CV and three names of references to:

Q. Richard Lu, PhD
Associate Professor
Department of Developmental Biology
UT Southwestern Medical Center
6000 Harry Hines Blvd.
Dallas, TX 75390-9133
Email: qrichard.lu@utsouthwestern.edu

UT Southwestern is an Equal Opportunity/Affirmative Action Employer.

Digestive and Liver Diseases, Department of Internal Medicine

There are no positions available at this time.
UT Southwestern is an Equal Opportunity/Affirmative Action Employer.

Department of Endocrinology 

There are no positions available at this time.
UT Southwestern is an Equal Opportunity/Affirmative Action Employer.

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Hematology Oncology, Department of Internal Medicine

Molecular Mechanisms of Advanced Prostate Cancer (217)

A postdoctoral position supported by the Howard Hughes Medical Institute is available in the laboratory of Dr. Nima Sharifi in the Division of Hematology/Oncology, Department of Internal Medicine.

Our laboratory is focused on molecular mechanisms of androgen receptor (AR) gain-of-function that lead to resistance to androgen deprivation therapy and the translational relevance thereof.  Areas of interest in this laboratory include:

• Metabolic and genetic changes required for androgen synthesis
• Animal models of advanced prostate cancer for translational and therapeutic studies
• Defining targets for the development of new pharmacologic therapies
• Clinical validation in patients and clinical trials utilizing innovative approaches

We have recently discovered that prostate cancer becomes resistant to hormonal therapy by the synthesis of dihydrotestosterone through a pathway that circumvents testosterone, instead requiring 5α-androstanedione, a previously underappreciated intermediate metabolite. This metabolic pathway occurs commonly in all models and patient tumors tested (Chang, et al. Proc Natl Acad Sci USA. 2011 Aug 16;108 [33]:13728-33). This work was featured as a Research Highlight in Nature Reviews Urology (Nat Rev Urol. 2011 Sep 8; 8 [9]:470) and given a “must read” review by the Faculty of 1000 (http://f1000.com/13200029). We have also shown that blocking the enzyme 3β-hydroxysteroid dehydrogenase stops the androgen-response from adrenal precursors, validating this as a potential pharmacologic target for the treatment of advanced prostate cancer (Evaul, et al. Endocrinology. 2010. 151[8]):3514-20).

The position will provide a unique and multidisciplinary exposure to tumor metabolism, molecular oncology, drug development and clinical trials. Further details are available on our Lab website.

UT Southwestern Medical Center is the home of five Nobel Laureates, 19 members of the National Academy of Sciences and 20 Members of the Institute of Medicine.

The candidate must hold a doctoral degree with a background in molecular biology, metabolism or cancer biology.  Candidates with an interest in the position should send their cv and contact information for 3 references to: 

Nima Sharifi, MD
Assistant Professor
Division of Hematology/Oncology
UT Southwestern Medical Center
5323 Harry Hines Blvd.
Dallas, TX 75390-8852
c/o Hem/Onc Research HemOncResearch@utsouthwestern.edu

UT Southwestern is an Equal Opportunity/Affirmative Action Employer.

Hypertension, Department of Internal Medicine 

There are no positions available at this time.
UT Southwestern is an Equal Opportunity/Affirmative Action Employer.

Department of Immunology

Antibody Engineering for the Development of Cancer Therapeutics (220)

Postdoctoral positions are available in the laboratory of Drs. E. Sally Ward and Raimund J. Ober at UT Southwestern Medical Center at Dallas. These positions are supported by recently acquired funds from the Cancer Prevention and Research Institute of Texas (www.cprit.state.tx.us). Postdoctoral appointees will work on projects involving the use of antibody engineering approaches to develop therapeutics for cancer that target growth factor receptors and exposed phosphatidylserine (PS). These studies will use a combination of in vitro and in vivo studies in mice to analyze therapeutic efficacy.

These projects have direct relevance to the rapidly expanding use of antibodies in the biopharma industry.

For more information on the research carried out in the laboratory see www4.utsouthwestern.edu/wardlab or publications such as J. Immunol., 187, 1015, 2011; Proc. Natl. Acad. Sci. USA, 106, 2788-2793, 2009; Traffic, 10, 600-614, 2009; Biophys J., 95, 6025-6043, 2008; Proc. Natl. Acad. Sci. USA, 104, 5889-5894, 2007; Proc. Natl. Acad. Sci. USA, 103, 4457-4462, 2006; Nature Biotechnol., 23, 1283-1288, 2005; Proc. Natl. Acad. Sci. USA, 101, 11076-11081, 2004; J. Immunol., 172, 2021-2029, 2004.

Highly motivated individuals with a Ph.D. in any biological area, (bio)engineering, biotechnology, or chemistry should apply. Relevant experience is desirable but is not essential.

If interested, please send CV and names/addresses of at least three referees to E. Sally Ward at wardlab@utsouthwestern.edu

Investigation of Mechanisms of Innate Control of Adaptive Immunity (178)

An NIH-funded postdoctoral position is available beginning August 2011 to study the mechanisms by which recognition of pathogens by Toll-Like Receptors (TLRs) influences different aspects of T cell activation and differentiation.

The appointment will be within the Department of Immunology, UT Southwestern Medical Center. Requirements include a PhD and/or an MD. Candidates with proven record of publications and a strong background in immunology, molecular biology, and biochemistry are encouraged to apply. Successful candidates will benefit from excellent research facilities and a collaborative environment.

Candidates can access the research interests of the lab.

Interested candidates should send their CV, a statement of research accomplishments and goals, and the names and addresses of three references to:

Chandrashekhar Pasare, PhD
Assistant Professor
Department of Immunology
UT Southwestern Medical Center
6000 Harry Hines Blvd
Dallas, TX 75390-9093
Email: chandrashekhar.pasare@utsouthwestern.edu

Development of Therapeutics for Autoimmunity (177)

Postdoctoral positions are available in the laboratory of Drs. E. Sally Ward and Raimund J. Ober at UT Southwestern Medical Center.

Postdoctoral appointees will work on projects involving the development and/or characterization of antibody-based therapeutics for autoimmunity. Positions are available to develop therapeutics to treat disease in mouse models of multiple sclerosis and arthritis using the following approaches:

• The use of antigen delivery vehicles to induce T cell tolerance.
• The use of engineered antibodies that target the Fc receptor, FcRn, that lower the levels of autoreactive antibodies.

These projects are funded by the National Multiple Sclerosis Society and National Institutes of Health and have direct relevance to the rapidly expanding use of antibodies in the biopharma industry.

More information on the research carried out in the lab is available in the following publications:

• Proc. Natl. Acad. Sci. USA, 106, 2788-2793, 2009
• Traffic, 10, 600-614, 2009
• J. Immunol., 182, 5268-5275, 2009
• J. Immunol., 181, 7550-7561, 2008
• Proc. Natl. Acad. Sci. USA, 103, 18709-18714, 2006
• Nature Biotechnol., 23, 1283-1288, 2005
• Proc. Natl. Acad. Sci. USA, 101, 11076-11081, 2004
• J. Immunol., 172, 2021-2029, 2004
• Biophys. J., 86, 1185-1200, 2004.

Highly motivated individuals with a PhD in any biological area will be considered. Relevant experience is desirable but not essential.

If interested, please send CV and names/addresses of at least three referees to:

E. Sally Ward at wardlab@utsouthwestern.edu

UT Southwestern is an Equal Opportunity/Affirmative Action Employer.

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Infectious Diseases, Department of Internal Medicine

Microbial Tuberculosis Pathogenesis and Bacterial Adaptations (183)

A postdoctoral research position is available to study M. tuberculosis pathogenesis focusing on bacterial adaptations to the host environment.

The candidate should be highly-motivated, have excellent oral and written communication skills, and have a strong foundation in molecular biology and biochemistry. PhD and/or MD required. Experience with microbial pathogenesis is desirable but not required.

Please send curriculum vitae and three letters of reference to:

Dr. Michael Shiloh
Department of Internal Medicine
Division of Infectious Diseases
UT Southwestern Medical Center
5323 Harry Hines Blvd.
Dallas, TX, 75390-9113
Email: michael.shiloh@utsouthwestern.edu

Immune Recognition and Pathogenesis of Autoimmune Diseases (174)

Postdoctoral research positions are available to study innate immune recognition of HIV, innate immune sensing of nucleic acids, and pathogenesis of autoimmune diseases.

PhD and/or MD required. The candidate should be highly-motivated, have excellent oral and written communication skills. Candidates should have strong foundation in molecular biology and immunology. Experience in HIV research is preferable, but not required.

Please send curriculum vitae and three letters of reference to:

Nan Yan, PhD
Department of internal Medicine
Division of Infectious Diseases
UT Southwestern Medical Center
5323 Harry Hines Blvd.
Dallas, TX, 75390.
Email: nan.yan@utsouthwestern.edu

UT Southwestern is an Equal Opportunity/Affirmative Action Employer.

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McDermott Center for Human Growth and Development

Molecular Genetics (181)

The McDermott Center for Human Growth and Development/Center for Human Genetics solicits applications for a postdoctoral research position in molecular genetics.

The successful candidate should have a PhD or MD/PhD and a background in biochemistry, molecular biology and/or cell biology. Applicants with proven knowledge, experience and facility in the techniques of cloning, DNA sequence analysis, tissue culture, recombinant protein expression and animal investigations will be carefully considered. Recent degree recipients are encouraged to apply.

Please email a letter of interest which includes a description of the candidate’s research interests and goals, along with updated curriculum vitae, and at least three professional references to:

Christine Kim Garcia, MD, PhD
McDermott Center for Human Growth and Development
UT Southwestern Medical Center
Email: christine.garcia@utsouthwestern.edu 

Statistical Genetics (172)

The McDermott Center for Human Growth and Development/Center for Human Genetics solicits applications for a postdoctoral research position in statistical genetics.

The research focus of the lab is methodological development of statistical genetics and genetic epidemiology including linkage, association, and population genetics toward the goal of uncovering the genetic bases of human complex traits.

Successful applicants should have a strong background in statistics, biostatistics, bioinformatics, genetic epidemiology, or population genetics, and should hold a PhD Programming skill in R is required and skills in Java/C are desired.

Please email a letter of interest which includes a description of the candidate’s research interests and goals, along with updated curriculum vitae, and at least three professional references to:

Chao Xing, PhD
McDermott Center for Human Growth and Development
UT Southwestern Medical Center
Email: chao.xing@utsouthwestern.edu 

UT Southwestern is an Equal Opportunity/Affirmative Action Employer.

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Department of Microbiology

Molecular Virology (184)

Two postdoctoral positions in molecular virology are available to investigate interactions between host innate immunity and gamma herpesviruses (human KSHV and mouse gHV-68). Emphasis will be placed on the elucidation of viral mechanisms to evade and exploit innate immune signaling pathways in infection and pathogenesis.

Motivated individuals should have a PhD in Microbiology, Biochemistry, or a related biological science and experience with molecular biology techniques as demonstrated by publications. The position offers the opportunity to carry out research in a dynamic research environment with outstanding resources and well-defined projects.

Send curriculum vitae and contact information for three references to:

Pinghui Feng, PhD
Department of Microbiology
UT Southwestern Medical Center
5323 Harry Hines Blvd.
Dallas, TX 75390-9048
Fax: 214-648-5905
Email: pinghui.feng@utsouthwestern.edu

UT Southwestern is an Equal Opportunity/Affirmative Action Employer.

Department of Molecular Biology

Genetic and Epigenetic Regulation of Neural Stem Cells and their Roles in Regeneration and Brain Tumors (179)
One fully funded postdoctoral position is available to study the regulation of neural stem cells and their roles in diseases. The project may focus on any of the following topics: transcriptional reprogramming, genetic and epigenetic mechanism controlling specification and maintenance of neural stem cells, and signaling pathways in gliomas. Combinations of techniques in molecular and cell biology, biochemistry, and mouse genetics will be employed.

Self-motivated individuals with a PhD degree and first-author publications in international journals are encouraged to apply. Candidates with demonstrated records in stem cells, neuroscience, molecular or developmental biology are preferred. The candidate is expected to work in a collaborative environment.

Please send curriculum vitae, description of research background and interests and contact information of three references to:

Chun-Li Zhang, PhD
Department of Molecular Biology
UT Southwestern Medical Center
6000 Harry Hines Blvd.
Dallas, TX 75390-9148.
Email: chun-li.zhang@utsouthwestern.edu

UT Southwestern is an Equal Opportunity/Affirmative Action Employer.

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Division of Nephrology, Department of Internal Medicine

There are no positions available at this time.
UT Southwestern is an Equal Opportunity/Affirmative Action Employer.

Department of Neurology

There are no positions available at this time.
UT Southwestern is an Equal Opportunity/Affirmative Action Employer.

Department of Neuroscience

There are no positions available at this time.
UT Southwestern is an Equal Opportunity/Affirmative Action Employer.

Department of Obstetrics and Gynecology

Biophysics and Chromatin Biology of Transcriptional Regulation (219)

Seeking highly motivated scientist with a PhD in Biochemistry, Biophysics, Chemistry or related field for a postdoctoral position to study chromatin biology and transcription in the laboratory of Dr. Xin Liu at the University of Texas Southwestern Medical Center. We are a member of the Cecil H. and Ida Green Center for Reproductive Biology Sciences and the Molecular Biophysics Graduate Program.

The research of our laboratory is focused on the regulation of chromatin organization and its impacts on transcription and human diseases. We are particularly interested in elucidating the molecular and biophysical basis of chromatin dynamics including chromatin looping mediated by macromolecular complexes during transcriptional activation and repression.

 Applicants with background and interest in structural biology, protein and nucleic acid biochemistry, chromatin and transcription biology, or biophysical methodology are encouraged to apply.

Candidates should submit a CV, a list of three references, and a brief statement of research accomplishments and career goals by email to: xin.liu@utsouthwestern.edu

UT Southwestern is an Equal Opportunity/Affirmative Action Employer.

Department of Ophthalmology

There are no positions available at this time.
UT Southwestern is an Equal Opportunity/Affirmative Action Employer.

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Department of Orthopaedic Surgery

Osteoarthritis Connective Tissue Repair and Mechanobiology (186)

The University of Texas Southwestern Medical Center, Department of Orthopaedic Surgery is recruiting a Post-doctoral Fellow to study osteoarthritis, connective tissue repair and mechanobiology. Motivated scientists interested in the areas of cell signaling, apoptosis, tissue repair and/or animal models of osteoarthritis are encouraged to apply.

Successful candidates will work on current and interdisciplinary topics in the area of osteoarthritis and cartilage biology. Applicants must hold doctoral-level degrees and have solid backgrounds as evidenced by publications in the areas of cell death, signaling, apoptosis or arthritis. Prior hands-on experience with NF-kB/MAPK signal pathways and cell apoptosis and/or mouse models is highly desirable. Recent PhD graduates familiar with research practices and procedures in the United States are especially encouraged to apply.

Qualified candidate should send curriculum vitae with publication record and the names and contact information of three references to:

Christopher C.T. Chen, PhD
Department of Orthopaedic Surgery
UT Southwestern Medical Center
5323 Harry Hines Blvd.
Dallas, TX 75390-8870
Phone: 214-648-2276
Email: chris.chen@utsouthwestern.edu

UT Southwestern is an Equal Opportunity/Affirmative Action Employer.

Department of Pathology 

There are no positions available at this time.
UT Southwestern is an Equal Opportunity/Affirmative Action Employer.

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Department of Pharmacology

Novel Glycogen Metabolism (185)

A postdoctoral position is available immediately in the Department of Pharmacology. The new postdoctoral fellow will study novel glycogen metabolism. The position will investigate glycogen breakdown in mammals for functions unrelated to energy homeostasis.

Candidates must hold a PhD or equivalent degree in area related to biochemistry and practical experience in either carbohydrate enzymology or glycogen metabolism.

Send CV and names of 3 references to:

Mark A. Lehrman, PhD
Professor, Department of Pharmacology
UT Southwestern Medical Center
6001 Forest Park Rd.
Dallas, TX 75390-9041
Email: mark.lehrman@utsouthwestern.edu

Bioinformatic Analysis (182)

A postdoctoral position is available to perform bioinformatic analysis of ChIP-seq and RNA-seq data on signaling proteins from pancreatic beta cells and lung cancers and to design and develop experiments to explore mechanisms and functions. 

PhD or equivalent required.  Experience in computer science or bioinformatics required and additional experience in genetics or transcription preferred.

Please submit a CV and three letters of reference to:

Melanie Cobb, PhD, Professor
Department of Pharmacology
UT Southwestern Medical Center
5323 Harry Hines Blvd.
Dallas, TX 75390-9041
Email: melanie.cobb@utsouthwestern.edu

Signal Transduction of Pheromone Cues In Drosophila (173)

A postdoctoral position is available immediately in the Department of Pharmacology. The new postdoctoral fellow will work as part of a team to undertake a large genetic screen to elucidate the signal transduction mechanisms underlying pheromone-induced behaviors in Drosophila melanogaster.

Candidates should hold a PhD or MD and have a strong background in genetics and/or electrophysiology.

Send CV to:
Dean Smith, MD, PhD
Associate Professor, Department of Pharmacology and Neuroscience
UT Southwestern Medical Center
5323 Harry Hines Blvd.
Dallas, TX 75390-9111

UT Southwestern is an Equal Opportunity/Affirmative Action Employer.

Department of Physiology

Membrane Domain-Driven Trafficking of Membrane Transporters (176)

A postdoctoral researcher position is available to study "liquid-ordered-domain-dependent endocytosis” and its role in regulating ion transporter and channels (see articles in J. Gen. Phys. 2011, vol. 137, issues 1 and 2).  The work employs innovative electrical and optical methods and requires analytical and technical expertise, as well as exceptional computer skills.

Candidates must have a PhD at the time of appointment.

Interested individuals should submit electronically their research interests, a curriculum vitae, publication list, and contact information for three references to:

Donald W. Hilgemann, PhD
UT Southwestern Medical Center
Department of Physiology
5323 Harry Hines Blvd.
Dallas, TX  75390-9040
Email: donald.hilgemann@utsouthwestern.edu

UT Southwestern is an Equal Opportunity/Affirmative Action Employer.

Department of Psychiatry

UT Southwestern is an Equal Opportunity/Affirmative Action Employer.

Pulmonary, Internal Medicine

There are no positions available at this time.
UT Southwestern is an Equal Opportunity/Affirmative Action Employer.

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Department of Radiation Oncology

Medical Physics (189)

A postdoctoral position in medical physics is available in the Department of Radiation Oncology. The successful candidate will work on projects related to image-guided radiation therapy (IGRT) using cone beam CT (CBCT), PET and fluoroscopic imaging.  

A PhD is required in medical physics, biomedical engineering, electrical engineering, physics, mechanical engineering, computer science, or related area of study. Experience in medical imaging (devices or image reconstruction), image-guided radiation therapy or molecular imaging is a plus.

Facility and Equipment: The Department of Radiation Oncology currently has 14 faculty-level physicists, two medical physics residents, 7 full time dosimetrists, two service and research engineers, and three IT specialists. The Department has a total of 14 physicians and 8 residents who provide services to over 140 patients per day treated on the main campus with state-of-the-art machines and techniques.

Our main facility has two Varian linear accelerators with dynamic MLC, one Varian Trilogy linear accelerator with OBI, an Elekta Synergy-S, an Elekta Gamma Knife Model 4C, Accuray Cyberknife, two Philips 16-slice Brilliance large-bore 4-D CT simulator, a GE CT simulator, two Calypso electromagnetic tracking systems, Varisource HDR, and Philips Pinnacle, Varian Eclipse and BrainLAB iPlan treatment planning systems. The department will be opening a second facility later this summer at UT Southwestern University Hospital—St. Paul, which will house two Varian True Beam linear accelerators and a BrainLAB Vero system.

Environment: With five Nobel Laureates and 19 members of the National Academy of Sciences currently on faculty, UT Southwestern Medical Center ranks among the top academic medical centers in the world. The Departments of Radiation Oncology and Radiology are an integral part of the NCI-designated Harold C. Simmons Comprehensive Cancer Center which provides exceptional opportunities for translation of laboratory science into clinical trials and provides an integrated program of medical, radiation, and surgical oncology. 

Applicants should submit CV with the names of at least three references to:

Jing Wang, PhD
Assistant Professor of Radiation Oncology
Email: jing.wang@utsouthwestern.edu.

Radiation Therapy Modeling, Response Analysis and Optical Imaging (171)

One postdoctoral position is available immediately in the Division of Molecular Radiation Biology/Department of Radiation Oncology.  General areas of research include: biological modeling (lung and prostate) for radiation therapy, analyze radiation response in vitro and in vivo and optical imaging. Candidate will also study the mechanisms underlying repair of radiation-induced DNA damage, cell cycle arrest and apoptosis. 

A skill in small animal surgery is a significant plus for this position. The successful candidate should hold a PhD degree in biochemistry, genetics, molecular biology, or other related fields, with significant experience in animal studies. The candidate must be self-motivated, possess strong problem solving and critical thinking skills, and be capable of working independently or with minimum supervision in a collaborative setting. Candidate must be able to handle more than one project and work in a fast-paced work environment.

Please provide curriculum vitae, a brief summary of research experience, names and contact information of three references to:

Debabrata Saha, PhD
Assistant Professor
Department of Radiation Oncology
Division of Molecular Radiation Biology
2201 Inwood Road
Dallas, TX 75390-9187
Phone: 214-648-7750
Fax: 214-648-5995
Email: debabrata.saha@utsouthwestern.edu

Radiation Therapy Treatment Planning and Dose Calculation (170)

The Department of Radiation Oncology at is seeking postdoctoral scholars to contribute to research efforts related to radiation therapy treatment planning and dose calculation. The successful candidate will work on plan evaluation and re-planning for on-line adaptive radiation therapy. Other general areas of research activity within the Division of Medical Physics and Engineering include: physical and biological modeling, image-guided and adaptive radiotherapy, and molecular imaging of response. Medical physics faculty collaborate closely with colleagues in the division of molecular radiation biology, other UT Southwestern departments, and other UT campuses. The Department has a CAMPEP accredited medical physics residency program and participates in the UT Southwestern Radiological Sciences Graduate Program.

Facility and Equipment: The Department of Radiation Oncology currently has 14 faculty-level physicists, two medical physics residents, 7 full time dosimetrists, two service and research engineers, and three IT specialists. The Department has a total of 13 physicians and 7 residents who provide services to over 140 patients per day treated on the main campus with state-of-the-art machines and techniques.  Our main facility has two Varian linear accelerators with dynamic MLC, one Varian Trilogy linear accelerator with OBI, an Elekta Synergy-S, an Elekta Gamma Knife Model 4C, Accuray Cyberknife, a Philips 16-slice Brilliance large-bore 4-D CT simulator, a GE CT simulator, two Calypso electromagnetic tracking systems, Varisource HDR, and Philips Pinnacle, Varian Eclipse and BrainLAB iPlan treatment planning systems.

Environment: With five Nobel Laureates and 19 members of the National Academy of Sciences currently on faculty, UT Southwestern Medical Center ranks among the top academic medical centers in the world. Its faculty members, who are responsible for a broad array of groundbreaking biomedical research advances, are respected for their dedication to teaching, training and patient care.  UT Southwestern, with over 12,000 faculty and staff, provides training to nearly 4,400 medical, graduate and allied health students, and residents and postdoctoral scholars each year. Ongoing support from federal agencies, private foundations, individuals and corporations provides more than $406 million per year to fund over 3,500 research projects. Faculty members and residents provide care to 100,000 inpatients and oversee 1.9 million outpatient visits per year at our ambulatory clinics. The Department of Radiation Oncology is part of the Harold C. Simmons Cancer Center which provides exceptional opportunities for translation of laboratory science into clinical trials and provides an integrated program of medical, radiation, and surgical oncology. 

Applicants must have a PhD degree in physics or a related field. Experience in radiation physics, MatLab and C programming is essential. Experience with radiation dose calculation is desired.

Please send CV and letter of interest to Weihua Mao at weihua.mao@utsouthwestern.edu

UT Southwestern is an Equal Opportunity/Affirmative Action Employer.

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Department of Radiology