Postdoctoral Training Opportunities

UT Southwestern Medical Center is committed to an educational and working environment that provides equal opportunity to all members of the University community. In accordance with federal and state law, the University prohibits unlawful discrimination, including harassment, on the basis of: race; color; religion; national origin; gender, including sexual harassment; age; disability; citizenship; and veteran status. In addition, it is UT Southwestern policy to prohibit discrimination on the basis of sexual orientation, gender identity, or gender expression.

Advanced Imaging Research Center Hematology Oncology, Internal Medicine Pathology
Biochemistry Human Growth and Development, Eugene McDermott Center
Pediatrics
Biophysics Hypertension, Internal Medicine Pharmacology
Cancer, Simmons Cancer Center Immunology Physiology
Cardiology, Internal Medicine Infectious Disease, Internal Medicine
Plastic Surgery
Cardiothoracic Surgery Microbiology Psychiatry
Cell Biology Mineral Metabolism, Internal Medicine Pulmonary, Internal Medicine
Center for Human Nutrition Molecular Biology
Radiation Oncology
Children's Research Institute at UT Southwestern Molecular Genetics
Radiology
Clinical Sciences
Nephrology, Internal Medicine Surgery
Dermatology Neurology and Neurotherapeutics Systems Biology, Cecil H. and Ida Green Center
Developmental Biology Neuroscience Therapeutic Oncology Research, Hamon Center
Digestive and Liver Diseases, Internal Medicine Obstetrics & Gynecology Urology
Endocrinology Ophthalmology
Genetics of Host Defense Center
Otolaryngology - Head & Neck Surgery

Advanced Imaging Research Center

Neuroimaging and Brain Connectivity (334)

The Advanced Imaging Research Center (AIRC) at UT Southwestern Medical Center is seeking a postdoctoral scholar with strong physical and neuroanatomical background. The candidate must have a Ph.D. or equivalent and should have a background in biomedical engineering, electronic engineering, biophysics, computer science or other related areas. Outstanding candidates with experience in diffusion MRI data acquisition/analysis, tractography analysis, and image analysis of developing brain connectome are encouraged to apply. Good computer programming skills in Matlab and C will be a plus.

Consideration of applications will begin immediately and continue until the position is filled. To apply send a CV, a brief statement of research interest, and contact information of three references to:

Hao Huang, Ph.D.
Advanced Imaging Research Center
University of Texas Southwestern Medical Center
5323 Harry Hines Blvd.
Dallas, TX 75390-8542
hao.huang@utsouthwestern.edu
Phone: 214-645-2881
Fax: 214-645-2885

Brain MR Spectroscopy (332)

The Advanced Imaging Research Center (AIRC) at UT Southwestern Medical Center is seeking one or two postdoctoral researchers to work in magnetic resonance spectroscopy (MRS) and imaging (MRI). We have several on-going MR projects developing new data acquisition/analysis strategy and applications in brain tumors in humans and animals. AIRC possesses research-dedicated several 3T and 7T whole-body MR scanners (Philips) and 9.4T horizontal-bore animal MR scanner (Agilent).

Candidates should have a Ph.D. or equivalent and background in experimental MRS/MRI. Outstanding candidates with experience in 1H/13C MRS data acquisition/analysis and MR sequence programming in the Philips environments are encouraged to apply. Good computer programming skills in MATLAB and C will be a plus.

Consideration of applications will begin immediately and continue until the position is filled.

To apply, send a CV with three references and a brief statement of research interest to:

Changho Choi, Ph.D.
Advanced Imaging Research Center
University of Texas Southwestern Medical Center
5323 Harry Hines Blvd.
Dallas, TX 75390-8542
Phone: 214-645-2805
Fax: 214-645-2885
changho.choi@utsouthwestern.edu

Non-Small Cell Lung Carcinoma (327)

A postdoctoral position is available in the laboratory of Matthew Merritt, Ph.D., in the Advanced Imaging Research Center of UT Southwestern Medical Center to study the effects of a novel treatment on the progression of non-small cell lung carcinoma. Our laboratory has several exciting projects related to physical, biological and medical sciences.

Candidates must hold a Ph.D. and/or M.D. degree. Projects will utilize NMR and/or MRI if necessary, and candidates with additional experience in intermediary metabolism considered are strongly encouraged to apply. Experience leading to publication in peer-reviewed journals is recommended.

Interested individuals should send a CV, statement of interests, and a list of three references to:
Matthew Merritt, Ph.D.
UT Southwestern Medical Center
5323 Harry Hines Blvd.
Dallas, TX 75390-9185
matthew.merritt@utsouthwestern.edu

Glucose and Lipid Metabolism (318)

A postdoctoral position is available in the laboratory of Eric Berglund, Ph.D., in the Advanced Imaging Research Center of UT Southwestern Medical Center to study glucose and lipid metabolism as well as energy balance using molecular and flux approaches. Our laboratory has several exciting projects related to physical, biological and medical sciences.

Candidates must hold a Ph.D. and/or M.D. degree. Projects will utilize mice and include genotyping, metabolic studies; surgery; and analyses using radioactivity, LC-MS/MS, GC-MS, and NMR. Experience in these skills, particularly surgery, is recommended. Prior experience writing and publishing in peer-reviewed journals is also recommended. Interested individuals should send a CV, statement of interests, and a list of three references to:

Eric Berglund, Ph.D.
Advanced Imaging Research Center
UT Southwestern Medical Center
5323 Harry Hines Blvd.
Dallas, TX 75390-9185
eric.berglund@utsouthwestern.edu

Intermediary Metabolism of Liver (316)

A postdoctoral position is available in the laboratory of Shawn Burgess, Ph.D., in the Advanced Imaging Research Center of UT Southwestern Medical Center to study the regulation of carbohydrate, lipid, and energy metabolism in liver using molecular and flux approaches. Our laboratory has several exciting projects related to physical, biological, and medical sciences.

Candidates must hold a Ph.D. and/or M.D. degree. Projects will utilize mouse phenotyping, molecular approaches, integrated physiology/metabolism, tracer methodologies, targeted metabolomics, LC-MS/MS, GC-MS, and NMR. Experience in some, but not necessarily all, of these areas is recommended. Experience leading to publication in peer-reviewed journals is recommended.

Interested individuals should send a CV, statement of interests, and a list of three references to:

Shawn Burgess, Ph.D.
Advanced Imaging Research Center
UT Southwestern Medical Center
5323 Harry Hines Blvd. 
Dallas, TX 75390-9185
shawn.burgess@utsouthwestern.edu

Biochemistry, Department of

Mass Spectrometry and Protemics (325)

A postdoctoral position is available in the Mirzaei Lab in the Department of Biochemistry at the University of Texas Southwestern Medical Center. This position is made available by funding from the Welch Foundation. This position is for one year, and reappointment beyond the first year of employment is contingent upon the availability of funding and satisfactory performance.

The successful applicant will have the opportunity to work on developing technology for identification of protein targets of small molecule drug candidates. The position will involve tissue culture, advanced HPLC, mass spectrometry utilizing the proteomics core facility at UT Southwestern led by Dr. Mirzaei, and bioinformatics. The mass spectrometry center at UTSW employs some of the most advanced instruments including QExactive plus, Orbitrap Elite, Quantiva, and 6500 Qtrap which will be available to the postdoctoral trainee.

Applicants must have a Ph.D. in Analytical Chemistry, Biochemistry, Chemistry, Biology, or related closely field. Proven track record of successful research and publication is required. Experience in HPLC, mass spectrometry, molecular biology, and biochemistry is highly valued.

Applications should be submitted online and must include a cover letter, full curriculum vitae, and statement of research interests. Three letters of reference should also be emailed directly to Dr. Mirzaei at hamid.mirzaei@utsouthwestern.edu.

Cancer Biomarker, Targeted Proteomics (326)

A postdoctoral position is available in the Mirzaei Lab in the Department of Biochemistry at the University of Texas Southwestern Medical Center. This position is made available by funding from Cancer Prevention Research Institute of Texas. This position is for one year, and reappointment beyond the first year of employment is contingent upon the availability of funding and satisfactory performance.

The successful applicant will work closely with members of Mirzaei lab, the proteomics core facility at UT Southwestern, and cancer center members pursuing high priority cancer targets. Thus, a dynamic, transdisciplinary and collaborative perspective will be highly valued. The mass spectrometry center at UTSW employs some of the most advanced instruments including QExactive plus, Orbitrap Elite, Quantiva and 6500 Qtrap which will be available to the postdoctoral trainee. This recruitment is for a project that is focused on developing SRM based biomarker assays in cancer. The position will involve tissue handling and processing, mass spectrometry and bioinformatics.

Applicants must have a Ph.D. in Analytical Chemistry, Biochemistry, Chemistry, Biology, or related closely field. Proven track record of successful research and publication is required. Experience in HPLC, mass spectrometry, molecular biology, and biochemistry is highly valued.

Applications should be submitted online and must include a cover letter, full curriculum vitae, and statement of research interests. Three letters of reference should also be emailed directly to Dr. Mirzaei at hamid.mirzaei@utsouthwestern.edu.

Biophysics, Department of

Biochemical and Biophysical investigation of RNA-mediated Gene Regulation (339)

The research group of Yunsun Nam, Ph.D. at UT Southwestern Medical Center is seeking a postdoctoral scholar. Our laboratory is housed in newly renovated space at the heart of the Cecil H. and Ida Green Center for Reproductive Biology Sciences, Department of Obstetrics and Gynecology at UT Southwestern Medical Center.

The overarching goal of our group is to elucidate the mechanistic details of RNA-regulated gene expression, by investigating the structure-function relationship of various protein/nucleic acid complexes. We are particularly interested in the gene regulation pathways relevant to mammalian development and cancer. Postdoctoral scholars will have many opportunities to learn the newest methods in biochemistry and biophysics, in addition to working in an exciting, fast-evolving area in the field of biological and biomedical sciences. We use various approaches, including X-ray crystallography, NMR spectroscopy, molecular biology, nucleic acid and protein biochemistry, high throughput sequencing, and eukaryotic cell-based studies. For more information, please refer to the lab website: www.ynamlab.org

Candidates must have a Ph.D. degree and a strong background in biochemistry (protein or nucleic acid) and/or structural biology. Interested individuals should submit a CV as a single pdf file, including contact information for 3 references, by email to: yunsun.nam@utsouthwestern.edu.

Cancer, Simmons Cancer Center

The role of gametogenic proteins in cancer (340)

A postdoctoral position is available in the laboratory of Angelique Whitehurst in the Simmons Cancer Center of UT Southwestern Medical Center to study the role of tumor-activated gametogenic proteins in supporting tumorigenic behaviors. Our laboratory has a number of projects related to cancer biology and the role of anomolously expressed proteins in tumorigenesis.

Candidates must hold a Ph.D. and/or M.D. degree. Experience in cell or molecular biology, biochemestry, and/or whole animal models is preferred. Applicants should have at least one first-author publication in a peer-reviewed journal.
Interested individuals should send a CV, statement of interests, and a list of three references to:
Angelique Whitehurst, Ph.D.
UT Southwestern Medical Center
5323 Harry Hines Blvd.
Dallas, TX 75390-8807
angelique.whitehurst@utsouthwestern.edu
Whitehurst Lab

Bioinformatics, Genomics and Personalized Medicine in Kidney Cancer (337)

A postdoctoral position is available for a highly-motivated scholar to work in the area of genomics and personalized medicine in kidney cancer. The project is focused on integrating high-throughput data from next-generation sequencing, gene expression, and other genetic and epigenetic analyses using clinical samples and pre-clinical models. The successful candidate will have the opportunity to be part of a team made up of researchers, physicians and clinical geneticists that cares for patients with kidney cancer and will be involved in the evaluation of personalized patient cancer genomes. The ultimate goal is to leverage understanding of the molecular genetics and biology of kidney cancer to improve patient treatments. For more information about the research program, please see, http://www3.utsouthwestern.edu/brugarolaslab/.

Candidates must have a Ph.D. in statistical genetics, bioinformatics, computer science, or a related field. The candidate should also have programming experience using Python, Perl, Java, or C/C++ and be familiar with tools such as R/Bioconductor or Matlab. A track record of productivity is essential. Successful applicants will have the opportunity to work in a translational research program spanning from molecular genetics to the clinic.

Interested candidates should send a CV, statement of research interests and the names of three references to:
James Brugarolas, M.D., Ph.D.
5323 Harry Hines Blvd.
Dallas, TX 75390-9133
james.brugarolas@utsouthwestern.edu

Molecular Mechanisms and Translational Research in Kidney Cancer (336)

A postdoctoral research scholar position is available in the Brugarolas lab for a highly-motivated scholar to study signaling mechanisms in renal cancer. For more information, visit the lab website

Candidates must hold a Ph.D. degree and have a track record of productivity with publications in well-established journals. Successful applicants will have the opportunity to work in a translational research program spanning from the molecular genetics to the clinic.

Interested candidates should send a CV, statement of research interests and the names of three references to:
James Brugarolas, M.D., Ph.D.
5323 Harry Hines Blvd.
Dallas, TX 75390-9133
james.brugarolas@utsouthwestern.edu

Cell Stress and Cancer Nanomedicine (335)

A postdoctoral position is now open for research focused on the effects of tumor-specific ‘NAD(P)H:quinone oxidoNQO1 bioactivatable’ drugs on altering cancer metabolism. The project will also develop novel noninvasive cancer imaging modalities of cancer metabolism.

Prospective candidates will have the opportunity to work in a highly productive multi-disciplinary environment with a team of experts in basic research using state-of-the-art cancer metabolism and imaging technology. Funding provided by a grant from the Pancreatic Action Network and American Association for Cancer Research. Salary will be dictated by NIH guidelines and the position is open only for junior postdoctoral candidates.

Applicants must hold a Ph.D. degree with strong background in cancer biology, molecular biology, and cancer metabolism. Candidates just out of their Ph.D. training will be preferred.

Please email curriculum vitae (CV), as well as names and contact information of three (3) references to:

David A. Boothman, Ph.D.
Professor, Department of Pharmacology
Associate Director for Translational Research
Simmons Comprehensive Cancer Center
University of Texas Southwestern Medical Center
Dallas, TX 75390-8807
david.boothman@utsouthwestern.edu

Chromatin Transcriptional Regulation (328)

A postdoctoral position is available to study mechanisms of chromatin-dependent transcription and posttranslational modification of transcription factors, cofactors and the general transcription machinery. In vitro-reconstituted chromatin transcription systems are frequently used in the lab to identify factors and pathways leading to gene activation and repression. Current focuses include transcription mechanisms and chromatin dynamics regulated by p53, AP-1, HPV-encoded E2 and E6 proteins, and Brd4 BET family proteins.

The candidate must have a Ph.D. and a strong background in transcription, chromatin, protein biochemistry, molecular biology is preferred.

Please forward your CV and names of three referees to:
Cheng-Ming Chiang, Ph.D.
Simmons Comprehensive Cancer Center
UT Southwestern Medical Center
5323 Harry Hines Blvd.
Dallas, TX 75390-8807
Phone: 214-645-6128
Fax: 214-645-6347
cheng-ming.chiang@utsouthwestern.edu

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Cell Biology

Mechanisms of cilium-generated signaling (342)

A postdoctoral research position is open in the laboratory of William J. Snell, Ph.D., in the Department of Cell Biology at UT Southwestern Medical Center to study cellular and molecular mechanisms of cilium-generated signaling using the green alga Chlamydomonas as a model system. The primary cilium is well established as a key sensory and signaling organelle that is essential for development and homeostasis. Disruption of ciliary structure/function in humans leads to multiple disorders collectively termed the ciliopathies. Attesting to the ancient function of the organelle in sensory transduction, Chlamydomonas uses its two flagella/cilia for signaling during sexual reproduction.

Chlamydomonas offers several advantages as a system for studying cilium-generated signaling and regulation of the protein composition of the ciliary membrane. In addition to being able to use genetic, molecular biological, and ultrastructural approaches, it is particularly simple to isolate cilia from Chlamydomonas in quantities sufficient for biochemical studies. We have several ongoing projects, but the project a candidate works on will be arrived at based on specific interests and background. Applicants must have a Ph.D. and research training appropriate for our system. To apply, please email a copy of your resume, contact information for at least 3 referees, and a cover letter outlining your research interests. Visit the Snell Lab to learn more about our research.

William J. Snell, Ph.D.
Department of Cell Biology
University of Texas Southwestern Medical Center
6000 Harry Hines Blvd.
Dallas, TX 75390-9039
Phone: 214-648-3966
william.snell@utsouthwestern.edu

Primary Cilia and Cellular Signaling Pathways (#311)

The focus of the current research in our laboratory is to understand mechanisms of cellular signaling at the level of the primary cilia, and its relevance to human health and disease. The first cellular organelle to be described in biology, the primary cilium was long mistaken as a vestigial appendage. The primary cilia are now considered as vital sensory organelles for detection and transmission of a broad range of chemical and mechanical signals in most cells. Signaling mediated by the primary cilia plays fundamental roles in cellular differentiation, polarity, and cell cycle control. We utilize a variety of biochemical, cell biological, and reverse genetic approaches to understanding signaling mediated by cilia, and dissecting their role during cell cycle control and carcinogenesis. A detailed description of current lab projects can be found at the Mukhopadhyay Lab

One postdoctoral position is available in our laboratory to study multiple aspects of ciliary signaling. Candidates must have a recent Ph.D. or M.D./Ph.D., with less than three years of prior postdoctoral experience, and a demonstrated research record with at least one first author publication. Preference will be given to applicants with a strong background in cell and molecular biology, protein biochemistry, or mouse genetics. Please email saikat.mukhopadhyay@utsouthwestern.edu a copy of your current curriculum vitae, contact information for references, and a cover letter highlighting your prospective research plan.

Dermatology, Department of

Molecular Mechanisms Regulating Tumorigenesis (314)

A postdoctoral research scholar position is immediately available in the laboratory of Lu Q. Le, M.D., Ph.D., in the Department of Dermatology and Simmons Comprehensive Cancer Center at UT Southwestern Medical Center.

This postdoctoral position is for highly motivated individuals interested in Cancer Biology and Stem Cell Biology to investigate early, initiating genetic and mircroenvironmental events that regulate tumorigenesis. Our research focuses on the identification of the cell origin and on elucidating the roles of microenvironment in tumor development.

We dissect the cellular and molecular mechanisms of carcinogensis from a developmental perspective using Neurofibromatosis Type 1 (NF1), a common tumor predisposition human genetic disorder, as a model. The laboratory is a collaborative effort between the Department of Dermatology and the Cancer Center, offering an extraordinarily rich environment that encompasses both basic and translational research. Candidates must hold a Ph.D., M.D./Ph.D., or M.D. degree and should possess good communication skills.
Interested candidates should send an updated CV, with names and contact information for three professional references, to:

Lu Q. Le, M.D., Ph.D.
Department of Dermatology
Simmons Comprehensive Cancer Center
UT Southwestern Medical Center
5323 Harry Hines Blvd.
Dallas, TX 75390-9069
lu.le@utsouthwestern.edu

Developmental Biology

Bioinformatics, Genomics, and Personalized Medicine in Kidney Cancer (337)

A postdoctoral position is available for a highly-motivated scholar to work in the area of genomics and personalized medicine in kidney cancer. The project is focused on integrating high-throughput data from next-generation sequencing, gene expression, and other genetic and epigenetic analyses using clinical samples and pre-clinical models. The successful candidate will have the opportunity to be part of a team made up of researchers, physicians and clinical geneticists that cares for patients with kidney cancer and will be involved in the evaluation of personalized patient cancer genomes. The ultimate goal is to leverage understanding of the molecular genetics and biology of kidney cancer to improve patient treatments. For more information about the research program, please see the Brugarolas Lab website

Candidates must have a Ph.D. in statistical genetics, bioinformatics, computer science, or a related field. The candidate should also have programming experience using Python, Perl, Java, or C/C++ and be familiar with tools such as R/Bioconductor or Matlab. A track record of productivity is essential. Successful applicants will have the opportunity to work in a translational research program spanning from molecular genetics to the clinic. 

Interested candidates should send a CV, statement of research interests and the names of three references to:
James Brugarolas, M.D., Ph.D.
5323 Harry Hines Blvd.
Dallas, TX 75390-9133
james.brugarolas@utsouthwestern.edu

Molecular Mechanisms and Translational Research in Kidney Cancer (336)

A postdoctoral research scholar position is available in the Brugarolas lab for a highly-motivated scholar to study signaling mechanisms in renal cancer. For more information, http://www3.utsouthwestern.edu/brugarolaslab/.

Candidates must hold a Ph.D. degree and have a track record of productivity with publications in well-established journals. Successful applicants will have the opportunity to work in a translational research program spanning from the molecular genetics to the clinic.

Interested candidates should send a CV, statement of research interests and the names of three references to:
James Brugarolas, M.D., Ph.D.
5323 Harry Hines Blvd.
Dallas, TX 75390-9133
james.brugarolas@utsouthwestern.edu

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Immunology, Department of

Pathogenic Mechanisms of M.Tuberculosis (329)

A postdoctoral position is available in the laboratory of Nicolai van Oers, Ph.D., in the Department of Immunology of UT Southwestern Medical center to study the pathogenic mechanisms of M. tuberculosis. Using RNA sequencing strategies, we have discovered a population of M. tuberculosis-encoded small RNAs (18-30 nucleotides) that are released in infected human macrophages. Several of these RNAs were also identified in the lung lesions of monkeys with latent tuberculosis infection.

Candidates must hold a Ph.D. and/or M.D. degree. We are seeking a postdoctoral researcher with molecular biology and/or biochemistry experience to identify and characterize a novel small RNA/microRNA-like processing system in mycobacteria. These studies are part of a collaborative effort with Tawanda Gumbo, M.D., with funding provided by the Gates Foundation. Interested individuals should send a CV, statement of interest, and a list of three references to:

Nicolai van Oers, Ph.D.
UT Southwestern Medical Center
5323 Harry Hines Blvd.
Dallas, TX 75390-9093
nicolai.vanoers@utsouthwestern.edu
van Oers Lab

Microbiology, Department of

Bacterial gene regulation and Lyme disease pathogenesis (341)

A postdoctoral position is available in the laboratory of Michael Norgard, Ph.D. in the Microbiology Department to study virulence gene regulation in Borrelia burgdorferi, the Lyme disease spirochete. Studies will focus on the RpoN (Sigma54)-RpoS alternative sigma factor regulatory cascade and, in particular, the role of BosR as an accessory molecule for pathway activation (see Z. Ouyang et al. 2010. BosR [BB0647] controls the RpoN-RpoS regulatory pathway and virulence expression in Borrelia burgdorferi by a novel DNA-binding mechanism. PLoS Pathogens 7: e1001272). The position offers the opportunity to conduct research in an attractive, dynamic research environment with outstanding resources. Candidates must have a Ph.D. with a background in bacterial genetics, gene regulation, bacterial pathogenesis, and molecular biology. Experience in spirochetology, animal models, and/or tick biology is preferred. Please send a C.V. and three letters of recommendation to:

Michael V. Norgard, Ph.D.
Chair, Department of Microbiology
U.T. Southwestern Medical Center
6000 Harry Hines Blvd.
Dallas, TX 75390-9048
michael.norgard@utsouthwestern.edu

Molecular Biology, Department of

Neural Regeneration Post Spinal Cord or Brain Injuries (323)

One fully funded postdoctoral position is immediately available in the laboratory of Chun-Li Zhang, Ph.D., at UT Southwestern Medical Center. The research focus of this position is to examine neural stem cells, cellular plasticity, induced neurogenesis, and regeneration after traumatic brain or spinal cord injuries. The ideal candidate must have a Ph.D. or equivalent degree, be self-motivated, have a solid publication record, and evidence of excellent skills in molecular, cellular, or electrophysiological neuroscience. Applicants should submit a CV and contact information of three references to:

Chun-Li Zhang, Ph.D.
W. W. Caruth, Jr. Scholar in Biomedical Research
UT Southwestern Medical Center
6000 Harry Hines Blvd.
Dallas, TX 75390-9148
chun-li.zhang@utsouthwestern.edu

Molecular Genetics, Department of 

Vascular Wall Pathologies and Neurodegenerative Diseases (333)

The Division of Vascular Surgery in the Department of Surgery is seeking individuals for a postdoctoral research position in the laboratory of Shirling Tsai, M.D.. Dr. Tsai collaborates closely with Joachim Herz, M.D., Professor of Molecular Genetics and Director of the Center for Alzheimer’s and Neurodegenerative Diseases. The Herz Lab studies lipoprotein receptor signaling mechanisms as they pertain to two major systems: vascular wall pathologies, such as aneurysms, atherosclerosis, and defects in the blood-brain-barrier, and neurodegenerative diseases. Dr. Tsai’s research in conjunction with the Herz Lab focuses on LDL Receptor Related Protein 1 (LRP1) and aortic aneurysm pathogenesis. This includes investigating protein-protein interactions with LRP1, intracellular signaling mechanisms governed by LRP1 in mouse aortic smooth muscle cells, and effects of LRP1 mutations in mouse models of aortic aneurysm. More information about LRP1 can be found at Herz Lab.

Candidates must have a Ph.D. and/or M.D. degree, relevant research experience, and have demonstrated experience in molecular and cellular biology, biochemistry, and mouse genetic models, as well as an ability to work independently and creatively. The lab is at the Dallas Veterans Affairs Medical Center, with some work at UT Southwestern Medical Center. Candidates must be either U.S. citizens or permanent residents.

Candidates should submit a curriculum vitae or resume, cover letter, and a list of three references by email to ebony.coleman-glenn@utsouthwestern.edu. The subject line should read “Postdoctoral Research Position – Vascular Biology.” Successful applicants will receive competitive pay and benefits commensurate with the applicant’s level of experience.

UT Southwestern provides a dynamic, collaborative, and integrative research and training environment with state-of-the-art facilities.

Nephrology, Division of

Cellular Mechanisms in Kidney Development and Disease (321)

A postdoctoral position is available in the laboratory of Denise Marciano, M.D., Ph.D., at UT Southwestern Medical Center. The overarching goal of the lab is to elucidate the mechanisms by which cells organize and differentiate to form tubules and glomeruli during kidney development, and to understand the pathogenic mechanisms that occur in kidney disease.

We are seeking a hard working individual with less than three years postdoctoral experience, and a strong publication record, and they must have a Ph.D. or M.D. degree. Applicants with experience in mouse genetics and molecular/cell biology are desired, but animal experience is not required. Please send via email a CV, a statement of research interests and career goals, and contact information for three references, to:

Denise K. Marciano, M.D., Ph.D.
UT Southwestern Medical Center
5323 Harry Hines Blvd. 
Dallas, TX 75390-8856
denise.marciano@utsouthwestern.edu

Neurology, Department of 

Cell Signaling and Cancer (320)

A postdoctoral training position is available to study signal transduction in cancer at the Department of Neurology and Neurotherapeutics, UT Southwestern Medical Center. Our laboratory focuses on the following major areas of research. 1) Receptor tyrosine kinase signaling in cancer, 2) how inflammatory signaling networks influence oncogenic signaling pathways and 3) synthetic lethal interactions in receptor tyrosine kinase signaling. We are particularly interested in the biology of glioma and use an approach combining in vitro experimental systems, mouse models and translational studies using human glioma tissue. The laboratory is located at the Dallas VA Medical Center, a major teaching hospital of UT Southwestern.

We are looking for an individual with a Ph.D. or M.D., Ph.D. degree who is highly motivated and hardworking with experience in molecular and cell biology and some evidence of research accomplishment. Experience working with a mouse model of cancer is strongly preferred. Our laboratory offers the opportunity to conduct high quality research in a supportive environment. 

Please send your CV, a statement of research interests, and the names of three references to amyn.habib@utsouthwestern.edu

Obstetrics and Gynecology, Department of

Biochemical and Biophysical investigation of RNA-mediated Gene Regulation (339)

The research group of Yunsun Nam, Ph.D., at UT Southwestern Medical Center is seeking a postdoctoral scholar. Our laboratory is housed in newly renovated space at the heart of the Cecil H. and Ida Green Center for Reproductive Biology Sciences, Department of Obstetrics and Gynecology at UT Southwestern Medical Center.

The overarching goal of our group is to elucidate the mechanistic details of RNA-regulated gene expression, by investigating the structure-function relationship of various protein/nucleic acid complexes. We are particularly interested in the gene regulation pathways relevant to mammalian development and cancer. Postdoctoral scholars will have many opportunities to learn the newest methods in biochemistry and biophysics, in addition to working in an exciting, fast-evolving area in the field of biological and biomedical sciences. We use various approaches, including X-ray crystallography, NMR spectroscopy, molecular biology, nucleic acid and protein biochemistry, high throughput sequencing, and eukaryotic cell-based studies. For more information, please refer to the lab website: www.ynamlab.org

Candidates must have a Ph.D. degree and a strong background in biochemistry (protein or nucleic acid) and/or structural biology. Interested individuals should submit a CV as a single pdf file, including contact information for 3 references, by email to: yunsun.nam@utsouthwestern.edu.

Hematophietic Stem Cells (338)

A postdoctoral position is available in the Bai Laboratory in the Green Center for Reproductive Biology of UT Southwestern Medical Center to study hematopoiesis development. Our laboratory has several exciting projects related to study transcriptional mechanisms that regulate the differentiation of hematopoietic stem cells (HSC). The potential project for this position will focus on identification of novel chromatin factors regulating HSC cell fate determination during normal and malignant hematopoiesis using a combination of genetic, biochemical, and genomic approaches.

Candidates must hold a Ph.D. and/or M.D. degree. Experience in genetics, molecular biology, or developmental biology leading to publication in peer-reviewed journals is recommended.

Interested individuals should send a CV, statement of interests, and a list of three references to:

Xiaoying Bai, Ph.D.
UT Southwestern Medical Center
5323 Harry Hines Blvd.
Dallas, TX 75390-8511
xiaoying.bai@utsouthwestern.edu
New faculty at the Green Center

Ophthalmology, Department of 

Genetics of Eye Disease (343)

A postdoctoral research opportunity in eye genetics is now available in the laboratory of V. Vinod Mootha, M.D., in the Department of Ophthalmology and the McDermott Center for Human Genetics at UT Southwestern Medical Center. Our NIH funded lab aims to identify novel genes underlying Fuchs’ endothelial corneal dystrophy and other anterior segment eye disorders. We are seeking a highly motivated fellow with a strong, proven publication record for a special opportunity to combine the new tools of genomics with functional studies. The candidate must hold a Ph.D. and/or M.D. degree and ideally have strong molecular and cellular biology skills. Qualified applicants should send a CV, a brief statement of research interests and goals, and contact information for three references to:
vinod.mootha@utsouthwestern.edu

V. Vinod Mootha, M.D.
UT Southwestern Medical Center
5323 Harry Hines Blvd.
Dallas, TX 75390-9057
Mootha Lab 

Postdoctoral Researcher in Cellular Mechanisms of Ocular Disease (331)

A postdoctoral position is currently available in the laboratory of John Hulleman, Ph.D. in the Department of Ophthalmology at the University of Texas Southwestern Medical Center. The Hulleman Laboratory is committed to understanding the underlying causes of inherited and idiopathic retinal disorders and developing novel therapies for them.

The successful candidate who will fill this position will apply chemical biology, functional genomics, and high-throughput screening approaches to understand the role of extracellular matrix proteins and stress-responsive signaling in the causation of retinal diseases. The candidate must be highly motivated and hardworking. The ideal candidate would be proficient in conventional molecular biology and biochemistry skills, protein analysis, and cell culture techniques.

Candidates must have a Ph.D. and/or M.D. degree, less than three years of postdoctoral experience, and a strong publication record.

Interested applicants should send a brief statement of research interests as well as their CV and contact information for 3 references as a single PDF to:

John Hulleman, Ph.D.
UT Southwestern Medical Center
5323 Harry Hines Blvd.
Dallas, TX 75390-9057
john.hulleman@utsouthwestern.edu

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Pharmacology, Department of 

Mechanism of G Protein Signal Control (330)

A postdoctoral researcher position is open in the laboratory of Elliot Ross in the Department of Pharmacology at UT Southwestern Medical Center to study molecular mechanisms of signal amplification, integration, and timing in receptor-G protein-effector systems. We are particularly interested in how receptors and G protein GAPs independently and cooperatively regulate signal amplitude and kinetics, and how multiple G protein inputs regulate effector proteins additively or synergistically. Multiple quantitative approaches and model systems are applicable to this research, both in cells and in reconstituted systems of purified proteins.

Specific projects will be determined by the person’s interests, talents and experience. I welcome suggestions for new projects or strategies. Our group tries to focus on essential mechanisms of molecular signaling and quantitative experimental approaches. Our group is in the Department of Pharmacology and Green Center for Systems Biology, and affiliated with the Cell Regulation and Molecular Biophysics Graduate Programs. You can learn more about our work at the Ross Lab website.

These projects, or their spin-offs, will attract people with diverse backgrounds. Strong applicants could come from a signaling background, or from other areas of biochemistry, biophysics, or systems biology. Applicants must hold a Ph.D. degree and demonstrate research experience appropriate to the project. Applications must include a CV, contact information for referees and a statement of research interests.

Elliott M. Ross, Ph.D.
Professor, Department of Pharmacology
Green Center for Systems Biology
University of Texas Southwestern Medical Center
6001 Forest Park Road
Dallas, TX 75230-9041
ross@utsw.swmed.edu

Physiology, Department of

Metabolic/Mitochondrial Regulation of Membrane Trafficking (317)

A postdoctoral scholar position is available to participate in new studies based on our recent discovery that mitochondria can regulate turnover of the surface membrane of cells to internal organelles. The successful candidate will be attracted to work in one or more of the following areas: (1) Development of GreenProtein/FRET sensors of cytoplasmic coenzyme A (CoA) and its metabolites, acyl CoA and acetyl Co A, for deployment in live-cells and real-time, (2) electrophysiological and optical studies of endocytosis that depends on mitochondrial metabolism and palmitoylation of membrane proteins, and/or (3) biochemical and electrophysiological studies of the regulation of membrane transporters by palmitoylation. Excellent molecular biological, laboratory, and computer skills are required. 

The ideal candidate must have a Ph.D. at the time of appointment. Interested individuals should submit electronically, a brief one-page description of research interests and plans, curriculum vitae, publications list, and contact information for three references to: 

Donald W. Hilgemann, Ph.D.
UT Southwestern Medical Center
5323 Harry Hines Blvd.
Dallas, TX 75390-9040
donald.hilgemann@utsouthwestern.edu.   

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Radiology, Department of

Chemistry for Molecular Imaging (315)

The Department of Radiology has recently established the Preclinical Nuclear Imaging Laboratory with research focus on design, synthesis, and biological evaluations of targeted imaging probes for noninvasive disease detection and therapy assessment by Positron Emission Tomography (PET) or Single Photon Emission Tomography (SPECT). Equipped with two state-of-the-art small animal scanners (a Siemens Inveon PET/CT Multimodality System and a Bioscan NanoSPECT/CT Plus system) and chemistry/radiochemistry/biology facilities, the Laboratory is poised to stand at the forefront of molecular imaging.

The Laboratory seeks a highly motivated individual to fill a postdoctoral research position for design and synthesis of molecular imaging probes. Candidates must have a Ph.D. in synthetic chemistry and career interests in molecular imaging. Hands-on experience with small animal imaging, medical radioisotopes, and live animals is desirable but not required.

Interested individuals should send their current curriculum vitae and the contact information for three references to:

Xiankai Sun, Ph.D.
Radiology & Advanced Imaging Research Center
UT Southwestern Medical Center
5323 Harry Hines Blvd.
Dallas, TX 75390-8542
xiankai.sun@utsouthwestern.edu

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UT Southwestern Medical Center is committed to an educational and working environment that provides equal opportunity to all members of the University community. In accordance with federal and state law, the University prohibits unlawful discrimination, including harassment, on the basis of: race; color; religion; national origin; gender, including sexual harassment; age; disability; citizenship; and veteran status. In addition, it is UT Southwestern policy to prohibit discrimination on the basis of sexual orientation, gender identity, or gender expression.

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