Postdoctoral Training Opportunities
Advanced Imaging Research Center
Whole Body MRI Screening (230)
An immediate opening for a postdoctoral research scholar is available in the Department of Radiology and Advanced Imaging Research Center at the University of Texas Southwestern Medical Center. The position will primarily focus on the development of alternative MRI techniques to diffusion-weighted imaging for whole-body screening of metastatic tumors under the mentorship of Dr. Ananth Madhuranthakam. The candidate must have a PhD in Biomedical/Electrical Engineering, Physics or related field, preferably with experience in pulse sequence programming and MATLAB/IDL. The candidate should have a track record of publications, excellent written and oral communication skills, and will be expected to participate in both independent and collaborative projects.
Outstanding instrumental resources are available including state-of-the-art dual-transmit 3T scanner and a 7T whole-body scanner dedicated to research. In addition, there are a number of small animal MR imagers, microCT, microPET and optical imaging devices along with excellent personnel resources, electronic and computing facilities. There will be opportunities for close interaction with other researchers and to develop additional research initiatives.
Interested applicants are invited to submit a CV including contact information of two references and a letter of interest to:
Ananth Madhuranthakam, PhD
ananth.madhuranthakam@utsouthwestern.edu
Development of New Endogenous Contrast Mechanisms (228)
A full time postdoctoral researcher position is available in the Department of Radiology and Advanced Imaging Research Center at University of Texas Southwestern Medical Center. Research is focused on the development of new endogenous contrast mechanisms, with specific emphasis on CEST. The project will include development of new pulse sequences, image analysis and theoretical models development. The research will be conducted on the dual transmit whole body 3T Philips scanner. Additional research opportunities will be explored using 7T whole body human scanner or small animal Varian 7T or 9.4T systems.
The position requires a PhD in physics, chemistry, biology or related field. The ideal candidate will have strong MRI or NMR background. Experience with pulse programming (such as Philips or Varian) is not mandatory, but would be an advantage.
Applicants are invited to send CV and the contact information of 2-3 references to Elena Vinogradov, PhD: elena.vinogradov@utsouthwestern.edu
Department of Biochemistry
Small Molecule Cancer Therapeutics (229)
A postdoctoral research scholar position is available for a candidate interested in targeted small molecule cancer therapeutics. The candidate would perform structural and biophysical studies to support ongoing drug discovery/design efforts. This position will begin as a visiting scientist in the lab of Nathanael Gray at the Dana Farber Cancer Institute in Boston to work in a highly productive and collaborative environment with medicinal chemists and chemical biologists. By the end of summer 2012, the scientist will move with the principal investigator, Dr. Kenneth Westover, to a new lab as a postdoctoral research scholar in the Department of Radiation Oncology at the University of Texas Southwestern Medical Center in Dallas.
Qualifications
A PhD or equivalent in a life or physical science is required. The ideal candidate will have experience with or a working knowledge of molecular biology, protein purification, biophysical methods, biochemical assay design, structural biology, chemical biology and cell biology. This is anticipated to be a highly collaborative position making good communication skills essential.
To apply send a curriculum vitae and contact information for three references to:
Kenneth Westover, MD, PhD
kenneth_westover@dfci.harvard.edu
Differential Profiling of Ubiquitinome via Proteomics (212)
A postdoctoral position is available immediately to investigate dynamics of ubiquitinome and ubiquitin-like proteomes using modern proteomics technologies. A successful candidate will use a combination of advanced separation techniques such as 2D Gel Electrophoresis (2D-GE) and 2D chromatography in conjunction with advanced mass spectrometry techniques developed in our lab to define and study the dynamics of ubiquitinome. A candidate should be proficient in 2D-GE, chromatography and immunopurification methods. A PhD and asolid background in molecular biology is required. Candidates with strong quantitative skills and separation science backgrounds are most highly desired. Previous experience with mass spectrometry is not required but can be a plus. A candidate must be strong in communication and analytical skills, focused and motivated to succeed, and able to work as a team as well as independently. Salary is commensurate with qualifications and experience (based on UT Southwestern scale). The position will be initially available for one year, with the renewal (up to 4-5 years) based on the performance and funding availability. The successful candidate will be encouraged to apply for independent fellowships to gain independent programs for his/her future career path. Email a cover letter (1-2 pages) outlining your research interest and career goal, current curriculum vitae, and name and email address of three-four referees to:
Hamid Mirzaei, PhD
Assistant Professor of Biochemistry
Director of Proteomics Core Facility
CPRIT Cancer Research Scholar
Department of Biochemistry
T. Boone Pickens Biomedical Building
6001 Forest Park Road
Dallas, TX 75390-9050
hamid.mirzaei@utsouthwestern.edu
UT Southwestern is an Equal Opportunity/Affirmative Action Employer.
Cardiology, Department of Internal Medicine
There are no positions available at this time.
UT Southwestern is an Equal Opportunity/Affirmative Action Employer.
Department of Cell Biology
There are no positions available at this time.
UT Southwestern is an Equal Opportunity/Affirmative Action Employer.
Center for Human Nutrition
There are no positions available at this time.
UT Southwestern is an Equal Opportunity/Affirmative Action Employer.
Department of Clinical Sciences
There are no positions available at this time.
UT Southwestern is an Equal Opportunity/Affirmative Action Employer.
Computational and Systems Biology
There are no positions available at this time.
UT Southwestern is an Equal Opportunity/Affirmative Action Employer.
Department of Dermatology
There are no positions available at this time.
UT Southwestern is an Equal Opportunity/Affirmative Action Employer.
Department of Developmental Biology
Developmental Neurobiology (221)
Postdoctoral fellow positions available for individuals with an interest in the transcriptional and epigenetic mechanisms of glial subtype development from neural stem cells and myelination in the vertebrate nervous system including miRNA and chromatin remodeling control as well as brain cancer formation. See recent publications from our laboratory: CELL, 109: 75-86; Nat. Neurosci. 4: 973-974; Nat. Neurosci. 12: 829-38; Nat. Neurosci. 12: 1398-406; and NEURON 25:17–329; NEURON, 65:612-626.
The ideal candidate should be a recent PhD graduate with self-motivation and a demonstrated record of publications in Molecular Biology, Biochemistry or Neuroscience. The successful applicants will use transgenic mouse models and genome-wide molecular approaches to unravel mechanisms of gliogenesis and brain tumorigenesis.
Please send your CV and three names of references to:
Q. Richard Lu, PhD
Associate Professor
Department of Developmental Biology
UT Southwestern Medical Center
6000 Harry Hines Blvd.
Dallas, TX 75390-9133
qrichard.lu@utsouthwestern.edu
UT Southwestern is an Equal Opportunity/Affirmative Action Employer.
Digestive and Liver Diseases, Department of Internal Medicine
There are no positions available at this time.
UT Southwestern is an Equal Opportunity/Affirmative Action Employer.
Department of Endocrinology
There are no positions available at this time.
UT Southwestern is an Equal Opportunity/Affirmative Action Employer.
Hematology Oncology, Department of Internal Medicine
Role of Protein Palmitoylation in Health and Disease (226)
Research Area: Molecular Biology and Biochemistry
Description of Project: A postodoctoral position is available in the laboratory of Dr. Sandra L. Hofmann to carry out CPRIT and privately funded projects to investigate the roles of protein palmitoylation in cancer and neurodegenerative disease. Applicants should have relevant experience in molecular biology, enzymology, cell culture and animal (mouse) models and have excellent oral and written English communication skills.
Only applicants with a recent PhD degree and a strong background in a basic science discipline need apply.
Please forward for CV/Biosketch and names and contact information for three references to:
Sandra L. Hofmann, MD, PhD
Department of Internal Medicine
Hamon Center for Therapeutic Oncology Research
UT Southwestern Medical Center
sandra.hofmann@utsouthwestern.edu
Molecular Mechanisms of Advanced Prostate Cancer (217)
A postdoctoral position supported by the Howard Hughes Medical Institute is available in the laboratory of Dr. Nima Sharifi in the Division of Hematology/Oncology, Department of Internal Medicine.
Our laboratory is focused on molecular mechanisms of androgen receptor (AR) gain-of-function that lead to resistance to androgen deprivation therapy and the translational relevance thereof. Areas of interest in this laboratory include:
- Metabolic and genetic changes required for androgen synthesis
- Animal models of advanced prostate cancer for translational and therapeutic studies
- Defining targets for the development of new pharmacologic therapies
- Clinical validation in patients and clinical trials utilizing innovative approaches
We have recently discovered that prostate cancer becomes resistant to hormonal therapy by the synthesis of dihydrotestosterone through a pathway that circumvents testosterone, instead requiring 5α-androstanedione, a previously underappreciated intermediate metabolite. This metabolic pathway occurs commonly in all models and patient tumors tested (Chang, et al. Proc Natl Acad Sci USA. 2011 Aug 16;108 [33]:13728-33). This work was featured as a Research Highlight in Nature Reviews Urology (Nat Rev Urol. 2011 Sep 8; 8 [9]:470) and given a “must read” review by the Faculty of 1000 (http://f1000.com/13200029). We have also shown that blocking the enzyme 3β-hydroxysteroid dehydrogenase stops the androgen-response from adrenal precursors, validating this as a potential pharmacologic target for the treatment of advanced prostate cancer (Evaul, et al. Endocrinology. 2010. 151[8]):3514-20).
The position will provide a unique and multidisciplinary exposure to tumor metabolism, molecular oncology, drug development and clinical trials. Further details are available on our Lab website.
UT Southwestern Medical Center is the home of five Nobel Laureates, 19 members of the National Academy of Sciences and 20 Members of the Institute of Medicine.
The candidate must hold a doctoral degree with a background in molecular biology, metabolism or cancer biology. Candidates with an interest in the position should send their cv and contact information for 3 references to:
Nima Sharifi, MD
Assistant Professor
Division of Hematology/Oncology
UT Southwestern
UT Southwestern is an Equal Opportunity/Affirmative Action Employer.
Hypertension, Department of Internal Medicine
There are no positions available at this time.
UT Southwestern is an Equal Opportunity/Affirmative Action Employer.
Department of Immunology
Antibody Engineering for the Development of Cancer Therapeutics (220)
Postdoctoral positions are available in the laboratory of Drs. E. Sally Ward and Raimund J. Ober at UT Southwestern Medical Center at Dallas. These positions are supported by recently acquired funds from the Cancer Prevention and Research Institute of Texas (www.cprit.state.tx.us). Postdoctoral appointees will work on projects involving the use of antibody engineering approaches to develop therapeutics for cancer that target growth factor receptors and exposed phosphatidylserine (PS). These studies will use a combination of in vitro and in vivo studies in mice to analyze therapeutic efficacy.
These projects have direct relevance to the rapidly expanding use of antibodies in the biopharma industry.
For more information on the research carried out in the laboratory see www4.utsouthwestern.edu/wardlab or publications such as J. Immunol., 187, 1015, 2011; Proc. Natl. Acad. Sci. USA, 106, 2788-2793, 2009; Traffic, 10, 600-614, 2009; Biophys J., 95, 6025-6043, 2008; Proc. Natl. Acad. Sci. USA, 104, 5889-5894, 2007; Proc. Natl. Acad. Sci. USA, 103, 4457-4462, 2006; Nature Biotechnol., 23, 1283-1288, 2005; Proc. Natl. Acad. Sci. USA, 101, 11076-11081, 2004; J. Immunol., 172, 2021-2029, 2004.
Highly motivated individuals with a Ph.D. in any biological area, (bio)engineering, biotechnology, or chemistry should apply. Relevant experience is desirable but is not essential.
If interested, please send CV and names/addresses of at least three referees to E. Sally Ward at wardlab@utsouthwestern.edu
Infectious Diseases, Department of Internal Medicine
Immune Recognition of HIV and Pathogenesis of Autoimmune Diseases (227)
A Postdoctoral scholar position is available to study innate immune recognition of HIV, innate immune sensing of nucleic acids, and pathogenesis of autoimmune diseases. PhD and/or MD is required. The candidate should be highly-motivated and have excellent oral and written communication skills. Candidates should have strong molecular biology and immunology background.
More information at the Yan Lab.
Please send curriculum vitae and three letters of reference to:
Nan Yan, PhD
Department of internal Medicine
Division of Infectious Diseases
University of Texas Southwestern Medical Center
5323 Harry Hines Blvd.
Dallas, TX, 75390
nan.yan@utsouthwestern.edu
McDermott Center for Human Growth and Development
UT Southwestern is an Equal Opportunity/Affirmative Action Employer.
Department of Microbiology
UT Southwestern is an Equal Opportunity/Affirmative Action Employer.
Department of Molecular Biology
There are no positions available at this time.
UT Southwestern is an Equal Opportunity/Affirmative Action Employer.
Division of Nephrology, Department of Internal Medicine
There are no positions available at this time.
UT Southwestern is an Equal Opportunity/Affirmative Action Employer.
Department of Neurology
There are no positions available at this time.
UT Southwestern is an Equal Opportunity/Affirmative Action Employer.
Department of Neuroscience
There are no positions available at this time.
UT Southwestern is an Equal Opportunity/Affirmative Action Employer.
Department of Obstetrics and Gynecology
Biophysics and Chromatin Biology of Transcriptional Regulation (219)
Seeking highly motivated scientist with a PhD in Biochemistry, Biophysics, Chemistry or related field for a postdoctoral position to study chromatin biology and transcription in the laboratory of Dr. Xin Liu at the University of Texas Southwestern Medical Center. We are a member of the Cecil H. and Ida Green Center for Reproductive Biology Sciences and the Molecular Biophysics Graduate Program.
The research of our laboratory is focused on the regulation of chromatin organization and its impacts on transcription and human diseases. We are particularly interested in elucidating the molecular and biophysical basis of chromatin dynamics including chromatin looping mediated by macromolecular complexes during transcriptional activation and repression.
Applicants with background and interest in structural biology, protein and nucleic acid biochemistry, chromatin and transcription biology, or biophysical methodology are encouraged to apply.
Candidates should submit a CV, a list of three references, and a brief statement of research accomplishments and career goals by email to: xin.liu@utsouthwestern.edu
UT Southwestern is an Equal Opportunity/Affirmative Action Employer.
Department of Ophthalmology
There are no positions available at this time.
UT Southwestern is an Equal Opportunity/Affirmative Action Employer.
Department of Orthopaedic Surgery
There are no positions available at this time.
UT Southwestern is an Equal Opportunity/Affirmative Action Employer.
Department of Pathology
There are no positions available at this time.
UT Southwestern is an Equal Opportunity/Affirmative Action Employer.
Department of Pharmacology
Cell Stress and Cancer Nanomedicine (224)
Research Area: Novel DNA double-strand (DSB) break repair in response to R-loop formation and DNA damaging agents. Biochemistry of transcriptional- and DSB repair-related complexes, as well as structure/function studies, will be performed.
Description of project: KUB5/HERA is a novel protein involved in both RNA transcription termination and repair of DSBs created by DNA damaging agents and/or R-loop (RNA-DNA hybrid) formation. Candidate will conduct epistasis analyses in yeast and mammalian cells to determine repair pathways in which Kub5/Hera functions. siRNA synthetic lethality analyses will also be performed. Biochemistry of DSB repair- and transcription-related protein complexes will also be analyzed.
Prospective candidates will have the opportunity to work in a highly productive multi-disciplinary environment with a team of experts in DNA damage checkpoint signaling, transcriptional complexes and R-loop formation, as well as higher DSB repair complexes.
Applicants must hold a PhD.degree with strong background in yeast genetics, biochemistry and DNA repair. Funding provided by NIH grant support and salary dictated by NIH guidelines.
Please email curriculum vitae (CV), as well as names and contact information of three (3) references to:
David A. Boothman, PhD
Professor, Department of Pharmacology
Associate Director for Translational Research
Simmons Comprehensive Cancer Center
UT Southwestern Medical Center
Dallas, Texas 75390-8807
Email: david.boothman@utsouthwestern.edu
Research Cell Stress and Cancer Nanomedicine (223)
Research Area: Cancer Metabolism and DNA Repair
Description of project: A postdoctoral position is now open for research focused on the effects of tumor-specific ‘NAD(P)H:quinone oxidoNQO1 bioactivatable’ drugs on altering cancer metabolism and DNA repair.
Prospective candidates will have the opportunity to work in a highly productive multi-disciplinary environment with a team of experts in basic and translational research using state-of-the-art DNA damage and repair technology, as well as novel nanotechnology delivery systems. Funding provided by NIH grant support and salary dictated by NIH guidelines.
Applicants must hold a PhD degree with strong background in cancer biology, molecular biology and cancer metabolism.
Please email curriculum vitae (CV), as well as names and contact information of three (3) references to:
David A. Boothman, PhD
Professor, Department of Pharmacology
Associate Director for Translational Research
Simmons Comprehensive Cancer Center
UT Southwestern Medical Center
Dallas, Texas 75390-8807
Email: david.boothman@utsouthwestern.edu
UT Southwestern is an Equal Opportunity/Affirmative Action Employer.
Department of Physiology
UT Southwestern is an Equal Opportunity/Affirmative Action Employer.
Department of Psychiatry
UT Southwestern is an Equal Opportunity/Affirmative Action Employer.
Pulmonary, Internal Medicine
Mechanisms of Lung Growth and Regeneration (231)
A postdoctoral research fellowship position is available for a motivated individual to study the mechanisms of lung growth and regeneration in NHLBI-supported projects. These projects use inter-disciplinary approaches to understand
- The in vivo signals and pathways responsible for induction of compensatory growth of gas exchange tissue in the lung,
- The integrated factors that determine whether and how lung tissue growth translates into functional improvement, and
- The potential for enhancement of lung growth and regeneration using targeted nanoparticle-facilitated pharmacotherapy.
These projects involve nanotechnology, pulmonary physiology, quantitative computer-aided image analysis of lung structure using advanced in vivo imaging techniques and light and electron microscopy, as well as cellular/molecular biology of growth factor signal transduction.
Candidates must have an MD, PhD, DVM, or equivalent degree. Interested candidates should send a letter, CV and the names of 2 to 3 references to:
Connie Hsia, MD
Dept. of Internal Medicine
UT Southwestern Medical Center
connie.hsia@utsouthwestern.edu
UT Southwestern is an Equal Opportunity/Affirmative Action Employer.
Department of Radiation Oncology
Small Molecule Cancer Therapeutics (229)
A postdoctoral research scholar position is available for a candidate interested in targeted small molecule cancer therapeutics. The candidate would perform structural and biophysical studies to support ongoing drug discovery/design efforts. This position will begin as a visiting scientist in the lab of Nathanael Gray at the Dana Farber Cancer Institute in Boston (http://graylab.dfci.harvard.edu/) to work in a highly productive and collaborative environment with medicinal chemists and chemical biologists. By the end of summer 2012, the scientist will move with the principal investigator, Dr. Kenneth Westover, to a new lab as a postdoctoral research scholar in the Department of Radiation Oncology at the University of Texas Southwestern Medical Center located in Dallas.
Qualifications
A PhD or equivalent in a life or physical science is required. The ideal candidate will have experience with or a working knowledge of molecular biology, protein purification, biophysical methods, biochemical assay design, structural biology, chemical biology and cell biology. This is anticipated to be a highly collaborative position making good communication skills essential.
To apply send a curriculum vitae and contact information for three references to:
Kenneth Westover, MD, PhD
kenneth_westover@dfci.harvard.edu
UT Southwestern is an Equal Opportunity/Affirmative Action Employer.
Department of Radiology
Whole Body MRI Screening (230)
An immediate opening for a postdoctoral research scholar is available in the Department of Radiology and Advanced Imaging Research Center at the University of Texas Southwestern Medical Center. The position will primarily focus on the development of alternative MRI techniques to diffusion-weighted imaging for whole-body screening of metastatic tumors under the mentorship of Dr. Ananth Madhuranthakam. The candidate must have a PhD in Biomedical/Electrical Engineering, Physics or related field, preferably with experience in pulse sequence programming and MATLAB/IDL. The candidate should have a track record of publications, excellent written and oral communication skills, and will be expected to participate in both independent and collaborative projects.
Outstanding instrumental resources are available including state-of-the-art dual-transmit 3T scanner and a 7T whole-body scanner dedicated to research. In addition, there are a number of small animal MR imagers, microCT, microPET and optical imaging devices along with excellent personnel resources, electronic and computing facilities. There will be opportunities for close interaction with other researchers and to develop additional research initiatives.
Interested applicants are invited to submit a CV including contact information of two references and a letter of interest to Ananth Madhuranthakam, PhD: ananth.madhuranthakam@utsouthwestern.edu
Trauma, Inflammation, Sepsis and Critical Care Program (222)
The Training Program in Trauma, Inflammation, Sepsis and Critical Care at The University of Texas Southwestern Medical Center offers a two-year mentored research training experience funded by an NIH T32 grant. The program is currently recruiting to fill two positions available beginning July 1, 2012. The program entails an individualized training plan developed by the mentor and trainee. The grant provides a stipend based on NIH guidelines for postdoctoral compensation as well as travel funds and health insurance.
Qualifications: Candidates must have an MD, PhD or equivalent degree from an accredited domestic or foreign institution. MDs must have completed a minimum of two years of residency in surgery, pediatrics or anesthesiology. NIH funding require that trainees hold U.S. citizenship or permanent residence.
To Apply: Interested applicants should submit their CV, a personal statement of goals and expectations, two letters of recommendation and proof of citizenship or permanent residency status.
Please direct applications and questions to Joy Lilljedahl at joy.lilljedahl@utsouthwestern.edu
UT Southwestern is an Equal Opportunity, Affirmative Action Employer
Department of Urology
MicroRNA in Prostate Cancer Metastasis and Gene Regulation (215)
A postdoctoral position, Postdoctoral Researcher II, is available to study the role of microRNA involved in prostate cancer metastasis and its gene regulation. A PhD or MD degree is required. Experiences in protein biochemistry, molecular and tumor/cell biology techniques are preferred. Since some animal experiments are expected, this person must be able to handle animals.
Please send curriculum vitae and names of three references to:
Jer-Tsong Hsieh, PhD
Department of Urology
UT Southwestern Medical Center
5323 Harry Hines Blvd.
Dallas, TX 75390-9110.
jt.hsieh@utsouthwestern.edu
UT Southwestern is an Equal Opportunity, Affirmative Action Employer