Monoclonal Antibodies

Well-characterized monoclonal antibodies are a valuable tool for both basic and clinical science. Typical licensing requests are for research or in vitro diagnostic use. Terms are flexible but generally include upfront fees and royalties.

UTSW Monoclonal Antibodies Available for Non-Exclusive Licensing

Internal Case NumberTitleLead ScientistPublication
0350 Monoclonal anti-human IL-6 Receptor antibody (UV4) Ellen S. Vitetta A Monoclonal Anti-Human IL-6 Receptor Antibody Inhibits the Proliferation of Human Myeloma Cells. Hybridoma 1993 Oct, 12 (5): 621-30. PMID: 8300137.
0372 Monoclonal antibodies to Sterol Regulatory Elements Binding Proteins (SREBP) 2A4 & 1C6 Michael S. Brown,
Joseph L. Goldstein
SREBP-2, a Second Basic-helix-loop-helix-leucine Zipper Protein that Stimulates Transcription by Binding to a Sterol Regulatory Element. Proc. Natl. Acad. Sci. U.S.A., Vol. 90, pp. 11603-11607, December 1993, Biochemistry.
1125 Monoclonal antibodies to heavy- and light-chain kinesin: H1, H2, L1 and L2 George S. Bloom Monoclonal Antibodies to Kinesin Heavy and Light Chains Stain Vesicle-like Structures, but not Microtubules, in Cultured Cells. J Cell Biol 1989 Apr; 108 (4) 1453-63.
1129 Anti-rat monoclonal antibody to Myogenin Woodring E. Wright Monoclonal Antimyogenin Antibodies Define Epitopes Outside the bHLH Domain where Binding Interferes with Protein-Protein and Protein-DNA Interactions. Dev Genet. 1996;19(2):131-8.
1292 Monoclonal antibody to human CD14 (61D3) J. Donald Capra Human CD14 Mediates Recognition & Phagocytosis of Apoptotic Cells. Nature, Vol 392, 2 April 1998.
1391 Mouse monoclonal antibody for LDLR (C7) Michael S. Brown,
Joseph L. Goldstein
Stoichiometric Binding of Low Density Lipoprotein (LDL) and Monoclonal Antibodies to LDL Receptors in a Solid Phase Assay. J. Biol. Chem., Vol. 264, No. 16, Issue of June 5, pp. 9533-9538, 1989.
1437 Mouse monoclonal antibody 58K-9, Golgi specificity George Bloom A Novel 58-kDa Protein Associates with the Golgi Apparatus and Microtubules. J Biol Chem, 264, 16083-16092 (1989)
1547 Monoclonal antibody anti-SCAP (9D5) Michael S. Brown,
Joseph L. Goldstein
Identification of Complexes between the COOH-terminal Domains of Sterol Regulatory Element-binding Proteins (SREBPs) and SREBP Cleavage-Activating Protein. J Biol Chem. Vol. 272, No. 32, Issue of August 8, pp.20213-20221, 1997.
1548 Mouse monoclonal antibody to very low density lipoprotein receptor VLDL-R (6A6) Michael S. Brown,
Joseph L. Goldstein
Low Density Lipoprotein Receptor-related Protein Mediates Endocytosis of Monoclonal Antibodies in Cultured Cells and Rabbit Liver. J. Biol. Chem. Vol. 265, No. 34, Issue of December 5, pp. 21355-21362, 1990.
1550 Mouse monoclonal antibody against recombinant human Rab escort protein-1 (2F1) Michael S. Brown,
Joseph L. Goldstein

Retinal Degeneration in Choroideremia: Deficiency of Rab Geranylgeranyl Transferase. Science, New Series, Vol. 259, No. 5093 (Jan. 15, 1993), pp. 377-381.

1550-2 Mouse monoclonal antibody against the alpha subunit of human farnesyl transferase (IB7) Michael S. Brown,
Joseph L. Goldstein
Mutational Analysis of alpha-Subunit of Protein Farnesyltransferase, Evidence for a Catalytic Role. J Biol Chem, Vol. 268, No. 2, Issue of January 15, pp. 1383-1390, 1993.
1718 Monoclonal antibodies to mouse Math1 protein Jane Johnson Autoregulation and Multiple Enhancers Control Math1 Expression in the Developing Nervous System. Development 127, 1185-1196 (2000).
1773 Mouse monoclonal antibody ATP-Binding Cassette Transporter G8 Helen Hobbs ABCG5 and ABCG8 Are Obligate Heterodimers for Protein Trafficking and Biliary Cholesterol Excretion. J Biol Chem. 2003 Nov 28;278(48):48275-82. Epub 2003 Sep 22.
1867 Mouse antibody with specificity for Human IgG (Heavy Chain) J. Donald Capra Initial Characterization of Monoclonal Antibodies Against Human Monocytes. Proc. Natl. Acad. Sci. U.S.A., Vol.77, No. 11, pp. 6764-6768, November 1980. Immunology.
2101 Monoclonal antibody against Cholesterol 24-Hydroxylase (1A7) David Russell

Neuronal Expression and Subcellular Localization of Cholesterol 24-hydroxylase in the Mouse Brain. J Comp Neurol. 2008 Apr 10;507(5):1676-93.