Available Technologies

UT Southwestern has a number of technologies available for licensing. 

Listed below are the cell lines created by Adi Gazdar, M.D., and John Minna, M.D., which are currently available to be licensed. Licensing inquiries should be submitted to Isamu Hartman, Ph.D. isamu.hartman@utsouthwestern.edu 

Additional technologies include:

Biologicals

UTSDTitleInventor
3133 1,4-Disubstituted and 1,4,5-Trisubstituted-1,2,3-Triazoles as Porcupine Inhibitors Lum
3100 High Concentration Gallium Nitrate Formulations for Disruption of Uropathogenic E. Coli Biofilms in Bladder Infection Zimmern
3097 Mouse Model for the Study of Heart Failure with Preserved Ejection Fraction Hill
3093 A Molecular Mimetic of Exercise Olson
3081 Gpr132 Inhibition as Novel Anti-Cancer Therapy Wan
3080 Compounds and Methods For Modulating C90RF72 Corey
3076 Use of RNA Interference Against Anln (Anillin) to Inhibit Cancer Growth Zhu
3049 Generation of knockout mice using CRISPR/Cas9 genome editing in spermatogonial stem cells Olson
3039 An Oral Combination Metformin and Psyflium Medication for Outpatient Weight Loss Hutchinson
3015 Design of Pathway Preferential Estrogens (PaPEs) Affording Beneficial Metabolic and Vascular Actions without Reproductive Tissue Stimulation Shaul
3009 Biological Activity of Biaryl Compounds Against Multidrug Resistant Pathogens and Cancer Kurti
3006 Direct Arene C-H Amination and Aza-Annulation Falck
3004 Methods and Compositions for Treatment of Atherosclerosis Herz
2991 Small Molecule Inhibitors of the Cancer Drug Target TAO2 Goldsmith
2982 Use of a Native Small Peptide Activator of the SERCA Pump for Treatment of Disease Caused by Calcium Overload Olson
2966 A Novel Nanoparticle Formulation of Erythropoietin Receptor (EpoR) and Antisense EpoR (ROPE) to Promote Lung Growth, Protection and Repair Hsia
2949 A Novel Formulation of Klotho cDMA or Recombinant Protein for Inhalation Delivery in the Prevention and Treatment of Lung Injury and the Promotion of Lung Growth and Repair Hsia
2934 Indolinyl-Sulfonamide Inhibitors of Tankyrase Lum
2922 A Method to Discover Molecules that Lower Cholesterol Levels in Human Cells Radhakrishnan
2899 Selective Killing of Metastasizing Melanoma Cells Through Inhibition of NADPH-Generating Folate Pathway Enzymes, ALDH1L1 and ALDH1L2 Morrison
2851 Allele Selective Inhibition of Mutant C90RF72 Foci Expression by Duplex RNAs Targeting the Expanded Hexanucleotide Corey
2833 Activation of Frataxin Expression: A Potential Treatment for Freidreich’s Ataxia Corey
2766 Novel Compound Supports Hematopoietic Stem Cells and Red Blood Cells Zhang
2763 A Method for Single Cell Sequencing of miRNAs and Other Difficult to Obtain Cellular RNAs Corey
2752 Identification and Isolation of Neural Stem Cells and Neurosphere-initiating Cells Morrison
2719 Treatment of Type 2 Diabetes, Cancer and Heart Failure by Inhibiting all four Mitochondrial Pyruvate Dehydrogenase Isoforms Chuang
2717 Novel Therapeutic Targets for the Anabolic Treatment of Osteoporosis and Uses Thereof Wan
2716 A Small Molecule Activator for MRTF-A Dependent Gene Expression Promotes Myofibroblast Differentiation and Wound Healing Olson
2714 Targeting HER2 and HER3 with Bispecific Antibodies in Breast Cancer Ward
2658 Highly Potent Inhibitors of Porcupine Lum
2655 Autophagy-Inducing Peptide Analogs Levine
2639 QseC-Inhibitors of Bacterial Virulence Sperandio
2625 Micro-RNAs that Inhibit Bone Resorption and Enhance Bone Formation and Uses Thereof Wan
2622 A Novel Hormone that Promotes Bone Resorption and Uses Thereof Wan
2586 Beclin Phosphorylation in Human Tumors as a Marker of Akt Activation, Autophagy Suppression by Akt, Predictor of Clinical Prognosis Levine
2535 Treating Cancers with Drugs Targeting CREB3L1 Ye
2429 Micro-RNAs Involved In Macular Degeneration Olson
2402 Oligonucleotide Modulation of Splicing Corey

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Devices

UTSDTitleInventor
3182 Patient Specific Soft Bolus for Radiotherapy Treatment Chui
3130 A Portable 3D Volumetric Ultrasound Image Guidance System for Prone Partial Breast Irradiation Jiang
3118 Total Internal Reflection Fluorescence Microscopy with Improved Background Suppression Fiolka
3110 A Method to Directly Produce Stable Sub-200 nm Nanodroplets of Very Low Boiling Point Perfluorocarbon That Have Narrow Size Distribution and High Concentration Particle Count Lux
3096 Clockface Pointer for Multiheaded Microscopes and other Imaging Devices Castrillon
3032 Range Guided Ion Beam Therapy Lu
3000 Light-Sheet Microscope with Parallelized 3D Image Acquisition Fiolka
2890 Biomimetic Fluoroscopic Films Welch
2864 Extended Focusing Illumination for 3D Microscopy Fiolka
2847 Perc Sac: A Device to Trap and Remove Kidney Stone Fragments Generated During Shock Wave Lithotripsy Antonelli
2741 Hardware and Software to Deliver Special Gas Mixtures to Humans Inside an MRI Scanner Lu
2732 Accelerator and Shielding Integrated System (ASIS) for Radiation Therapy Choy
2633 Vascular Trapping Sheaths and Vascular Trapping Guide Catheters for Endovascular Interventions and Diagnostic Angiography Banerjee
2451 Devices and Methods for Removal of Kidney Stones Cadeddu

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Diagnostics

UTSDTitleInventor
3176 Automated Process for Discovering Disease Biomarkers in the Antibody Repertoire Ostmeyer
3175 Biomarkers for Prediction of Immunotherapy Toxicity Gerber
3139 Tumor-Specific Polypeptide 1 (TSP1) and TSP1-specific Polyclonal Antibodies as a Biomarker and Diagnostic Tool in Breast and Other Cancers Kraus
3099 XRN2 Loss in Cancers Represents an Exploitable Cancer Vulnerability for Specific Therapies Boothman
2938 Blood Biomarker for Autism Spectrum Disorder German
2825 Markers for Assessing Differential Risk for Developing Heart Failure de Lemos
2814 KubS-Hera (RPRDlB) Deficiency as a Clinically Relevant Biomarker of PARP Inhibitor Sensitivity in BRCA-Proficient Cancers Boothman
2679 A Blood-Based Screening Tool for Alzheimer's Disease German
2642 Mapping Cell Identity Determinants in Chromatin Otwinowski
Borek
2627 Gene Signature Predicts Adenocarcinoma Prognosis And Therapeutic Response Xie
2567 Methods for Accurate Sequencing of DNA Otwinowski
2460 Genes Regulated by Methylation (GRMs) in Non-Small Lung Cancers (NSCLC) as Potential Markers for Cancer, Drug Response, and Epithelial-to-Mesenchymal Transition (EMT) Minna
2458 An Epithelial-Mesenchymal Transition (EMT) Gene Expression Signature for Characterizing the EMT Status of Epithelial Cancers Minna

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